Article: article from journal or magazin.
CD4+CD56+ hematodermic neoplasms bear a plasmacytoid dendritic cell phenotype.
Publication types: Journal ArticlePublication Status: ppublish
CD4+CD56+ hematodermic neoplasms (HNs) with initial presentation in the skin are characterized by highly aggressive behavior and poor prognosis. Recent studies indicate that malignant cells, which are devoid of common T-, B-, NK-, and myeloid lineage markers, may be of plasmacytoid dendritic cell (pDC) origin. We undertook a study to assess the expression of several pDC-associated molecules on a series of 5 CD4+CD56+ HN cases. CD123 was expressed in all 5 cases, with some heterogeneity in individual cases. All but one case revealed fine membranous BDCA-2 staining of the dermal infiltrate. pDC-like phenotype of the malignant infiltrating cells was confirmed by costaining of BDCA-2+ cells with CD123 and CD4. MxA protein, representing the surrogate marker for lesional type I interferon activity, was expressed in 4 of 5 evaluated cases. Our findings further substantiate the putative pDC origin of CD4+CD56+ HNs.
Adult, Aged, Antigens, CD4/analysis, Antigens, CD56/analysis, Cell Lineage, Dendritic Cells/immunology, Dendritic Cells/pathology, Female, GTP-Binding Proteins/analysis, Humans, Immunophenotyping, Interleukin-3 Receptor alpha Subunit, Lectins, C-Type/analysis, Lymphoma/immunology, Lymphoma/pathology, Male, Membrane Glycoproteins/analysis, Middle Aged, Receptors, Immunologic/analysis, Receptors, Interleukin-3/analysis, Skin Neoplasms/immunology, Skin Neoplasms/pathology, Tumor Markers, Biological/analysis
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