Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer.

Details

Serval ID
serval:BIB_66A9B9D7A511
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer.
Journal
Clinical Cancer Research
Author(s)
Schmidt M., Hasenclever D., Schaeffer M., Boehm D., Cotarelo C., Steiner E., Lebrecht A., Siggelkow W., Weikel W., Schiffer-Petry I., Gebhard S., Pilch H., Gehrmann M., Lehr H.A., Koelbl H., Hengstler J.G., Schuler M.
ISSN
1078-0432
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
14
Number
18
Pages
5849-5855
Language
english
Abstract
PURPOSE: Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention not only as a prognostic factor in breast cancer but also as a potential target for immunotherapy. We examined Ep-CAM expression in 402 consecutive node-negative breast cancer patients with long-term follow-up not treated in the adjuvant setting. EXPERIMENTAL DESIGN: Ep-CAM expression was evaluated by immunostaining. Its prognostic effect was estimated relative to overexpression/amplification of HER-2, histologic grade, tumor size, age, and hormone receptor expression. RESULTS: Ep-CAM status was positive in 106 (26.4%) patients. In multivariate analysis, Ep-CAM status was associated with disease-free survival independent of age, pT stage, histologic grade, estrogen receptor (ER), progesterone receptor (PR), as well as HER2 status (P = 0.028; hazard ratio, 1.60; 95% confidence interval, 1.05-2.44). Recently, so-called triple-negative (HER-2, ER, and PR) breast cancer has received increased attention. We noticed a similar association of Ep-CAM with disease-free survival in the triple-negative group as for the entire cohort. CONCLUSION: In this study of untreated breast cancer patients, Ep-CAM overexpression was associated with poor survival in the entire cohort and in the subgroup of triple-negative breast cancer. This suggests that Ep-CAM may be a well-suited target for specific therapies particularly in HER-2-, ER-, and PR-negative tumors.
Keywords
Adult, Aged, Aged, 80 and over, Antigens, Neoplasm, Breast Neoplasms, Cell Adhesion Molecules, Drug Delivery Systems, Female, Humans, Lymphatic Metastasis, Middle Aged, Neoplasms, Hormone-Dependent, Prognosis, Tumor Markers, Biological
Pubmed
Web of science
Open Access
Yes
Create date
03/03/2009 11:14
Last modification date
20/08/2019 14:22
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