Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla.

Détails

ID Serval
serval:BIB_6694CD9B7B05
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla.
Périodique
Journal of cerebral blood flow and metabolism
Auteur(s)
Boillat Y., Xin L., van der Zwaag W., Gruetter R.
ISSN
1559-7016 (Electronic)
ISSN-L
0271-678X
Statut éditorial
In Press
Peer-reviewed
Oui
Pages
271678X19831022
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Résumé
Negative blood oxygenation-level dependent (BOLD) signal observed during task execution in functional magnetic resonance imaging (fMRI) can be caused by different mechanisms, such as a blood-stealing effect or neuronal deactivation. Electrophysiological recordings showed that neuronal deactivation underlies the negative BOLD observed in the occipital lobe during visual stimulation. In this study, the metabolic demand of such a response was studied by measuring local metabolite concentration changes during a visual checkerboard stimulation using functional magnetic resonance spectroscopy (fMRS) at 7 Tesla. The results showed increases of glutamate and lactate concentrations during the positive BOLD response, consistent with previous fMRS studies. In contrast, during the negative BOLD response, decreasing concentrations of glutamate, lactate and gamma-aminobutyric acid (GABA) were found, suggesting a reduction of glycolytic and oxidative metabolic demand below the baseline. Additionally, the respective changes of the BOLD signal, glutamate and lactate concentrations of both groups suggest that a local increase of inhibitory activity might occur during the negative BOLD response.
Mots-clé
Functional magnetic resonance imaging, brain metabolism, functional magnetic resonance spectroscopy, inhibition, negative blood oxygenation–level dependent, neurovascular coupling, positive blood oxygenation–level dependent, visual stimulation
Pubmed
Création de la notice
25/03/2019 10:46
Dernière modification de la notice
21/08/2019 6:12
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