Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors.
Details
Serval ID
serval:BIB_666A41D53F60
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors.
Journal
European Heart Journal
Working group(s)
Reference Values for Arterial Measurements Collaboration
Contributor(s)
Boutouyrie P., Laurent S., Jouven X., Empana JP., Bozec E., Simon T., Pannier B., Mattace-Raso FU., Hofman A., Franco OH., Kavousi M., van Rooij FJ. , Witteman J., Rietzschel E., Vermeersch S., Segers P., Van Bortel L., De Bacquer D., Van Daele C., De Buyzere M., Bots ML., van der Schouw YT. , Grobbee DE., Uiterwaal CS., Evelein A., van der Graaf Y., Visseren FL., Stehouwer C., Ferreira I., Dekker J., Nijpels G., Twisk J., Smulders Y., Schalkwijk C., van Greevenbroek M., van der Kallen C., van de Laar R., Feskens E., Staessen J., Thijs L., Kouznetsova T., Jin Y., Liu Y., Benetos A., Labat C., Lacolley P., Wang J., Li Y., Fischer J., Terris D., Jarczok M., Thole M., Heuten H., Goovaerts I., Ennekens G., Vrints C., Ryliskyte L., Laucevicius A., Ryliskiene K., Kuzmickiene J., Bianchini E., Ghiadoni L., Bruno RM., Cartoni G., Taddei S., Tolezani EC., Hong V., Bortolotto L., Vermeer C., Braam L., Knapen M., Drummen N., Rimoldi SF., Stucki F., Hutter D., Rexhaj E., Faita F., Sartori C., Scherrer U., Allemann Y., Delahousse M., Karras A., Giannattasio C., Cesana F., Nava S., Maloberti A., Kollai£££Márk£££ M. , Pintér A., Horváth£££Tamás£££ T. , Narkiewicz K., Szyndler A., Hoffmann£££Michał£££ M. , Nowak R., Polonis K., Thuillez C., Joannidès R., Bellien J., Angel K., Atar D., Filipovský J., Agharazii M.
ISSN
1522-9645 (Electronic)
ISSN-L
0195-668X
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
34
Number
30
Pages
2368-2380
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish. C. Sartori fait partie de "Reference Values for Arterial Measurements Collaboration"
Abstract
AIMS: Common carotid artery intima-media thickness (CCIMT) is widely used as a surrogate marker of atherosclerosis, given its predictive association with cardiovascular disease (CVD). The interpretation of CCIMT values has been hampered by the absence of reference values, however. We therefore aimed to establish reference intervals of CCIMT, obtained using the probably most accurate method at present (i.e. echotracking), to help interpretation of these measures.
METHODS AND RESULTS: We combined CCIMT data obtained by echotracking on 24 871 individuals (53% men; age range 15-101 years) from 24 research centres worldwide. Individuals without CVD, cardiovascular risk factors (CV-RFs), and BP-, lipid-, and/or glucose-lowering medication constituted a healthy sub-population (n = 4234) used to establish sex-specific equations for percentiles of CCIMT across age. With these equations, we generated CCIMT Z-scores in different reference sub-populations, thereby allowing for a standardized comparison between observed and predicted ('normal') values from individuals of the same age and sex. In the sub-population without CVD and treatment (n = 14 609), and in men and women, respectively, CCIMT Z-scores were independently associated with systolic blood pressure [standardized βs 0.19 (95% CI: 0.16-0.22) and 0.18 (0.15-0.21)], smoking [0.25 (0.19-0.31) and 0.11 (0.04-0.18)], diabetes [0.19 (0.05-0.33) and 0.19 (0.02-0.36)], total-to-HDL cholesterol ratio [0.07 (0.04-0.10) and 0.05 (0.02-0.09)], and body mass index [0.14 (0.12-0.17) and 0.07 (0.04-0.10)].
CONCLUSION: We estimated age- and sex-specific percentiles of CCIMT in a healthy population and assessed the association of CV-RFs with CCIMT Z-scores, which enables comparison of IMT values for (patient) groups with different cardiovascular risk profiles, helping interpretation of such measures obtained both in research and clinical settings.
METHODS AND RESULTS: We combined CCIMT data obtained by echotracking on 24 871 individuals (53% men; age range 15-101 years) from 24 research centres worldwide. Individuals without CVD, cardiovascular risk factors (CV-RFs), and BP-, lipid-, and/or glucose-lowering medication constituted a healthy sub-population (n = 4234) used to establish sex-specific equations for percentiles of CCIMT across age. With these equations, we generated CCIMT Z-scores in different reference sub-populations, thereby allowing for a standardized comparison between observed and predicted ('normal') values from individuals of the same age and sex. In the sub-population without CVD and treatment (n = 14 609), and in men and women, respectively, CCIMT Z-scores were independently associated with systolic blood pressure [standardized βs 0.19 (95% CI: 0.16-0.22) and 0.18 (0.15-0.21)], smoking [0.25 (0.19-0.31) and 0.11 (0.04-0.18)], diabetes [0.19 (0.05-0.33) and 0.19 (0.02-0.36)], total-to-HDL cholesterol ratio [0.07 (0.04-0.10) and 0.05 (0.02-0.09)], and body mass index [0.14 (0.12-0.17) and 0.07 (0.04-0.10)].
CONCLUSION: We estimated age- and sex-specific percentiles of CCIMT in a healthy population and assessed the association of CV-RFs with CCIMT Z-scores, which enables comparison of IMT values for (patient) groups with different cardiovascular risk profiles, helping interpretation of such measures obtained both in research and clinical settings.
Pubmed
Web of science
Open Access
Yes
Create date
22/01/2013 14:59
Last modification date
20/08/2019 14:22
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