CT imaging findings of invasive pulmonary fungal infections in hemato-oncologic children.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_666040BE88C6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
CT imaging findings of invasive pulmonary fungal infections in hemato-oncologic children.
Journal
Insights into imaging
Author(s)
Alamo L., Ceppi F., Tenisch E., Beigelman-Aubry C.
ISSN
1869-4101 (Print)
ISSN-L
1869-4101
Publication state
Published
Issued date
12/12/2024
Peer-reviewed
Oui
Volume
15
Number
1
Pages
296
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Hemato-oncologic children form a heterogeneous group with a wide spectrum of ages, malignancy types, and immunosuppression grades during the different phases of their treatment. Immunosuppression is caused by multiple factors, including the malignancy itself, bone marrow suppression secondary to therapy, and wide use of steroids and antibiotics, among others. At the same time, the risk of infections in these patients remains high because of prolonged hospitalizations or the need for long-timing implanted devices between other features. In this context, a pulmonary fungal infection can rapidly turn into a life-threatening condition that requires early diagnosis and appropriate management. This pictorial essay illustrates the main imaging findings detected in chest computed tomography examinations performed in pediatric hemato-oncologic patients with proven pulmonary invasive fungal infections caused by Candida, Aspergillus, or Mucor. In addition, it describes useful clues for limiting differential diagnoses, reviews the literature on pediatric patients, and compares imaging findings in adults and children. CRITICAL RELEVANCE STATEMENT: The main fungal pathogens causing invasive fungal infections (IFI) in hemato-oncologic children are Candida, Aspergillus, and Mucor. This review describes the most frequently affected organs and the most common imaging findings detected in chest CT exams in children with pulmonary IFI. KEY POINTS: To review the main computed tomography imaging findings suggesting pulmonary invasive fungal infection (IFI) in hemato-oncologic children. To describe differences between pediatric and adult patients with proven pulmonary IFI. To provide useful clues for limiting the differential diagnosis of pulmonary IFI in pediatric patients.
Keywords
Aspergillosis, Mucormycosis, Pulmonary invasive fungal infections
Pubmed
Web of science
Open Access
Yes
Create date
16/12/2024 16:25
Last modification date
21/01/2025 7:20
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