Clinical applications of TNF-alpha in cancer
Details
Serval ID
serval:BIB_66562675C08E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Clinical applications of TNF-alpha in cancer
Journal
Current Opinion in Immunology
ISSN
0952-7915 (Print)
Publication state
Published
Issued date
10/1998
Volume
10
Number
5
Pages
573-80
Notes
Journal Article
Review --- Old month value: Oct
Review --- Old month value: Oct
Abstract
High-dose TNF-alpha plus chemotherapy, with or without IFN-gamma, can be safely administered regionally through isolated limb perfusion. This procedure produced between 70% and 80% complete remission in cases of in transit melanoma metastases and between 25% and 36% complete remission in cases of inextirpable soft-tissue sarcomas. Dual targeting is involved; TNF-alpha and IFN-gamma induce apoptosis of angiogenic endothelium, while melphalan induces apoptosis of tumour cells.
Keywords
*Chemotherapy, Cancer, Regional Perfusion
Dose-Response Relationship, Drug
Endothelium, Vascular/physiology
Humans
Interferon Type II/physiology
Melanoma/therapy
Neoplasms/blood supply/immunology/*therapy
Neovascularization, Pathologic/prevention & control
Sarcoma/therapy
Tumor Necrosis Factor-alpha/*administration & dosage
Pubmed
Web of science
Create date
28/01/2008 9:36
Last modification date
20/08/2019 15:22
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