Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg).

Details

Serval ID
serval:BIB_6648739851BC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg).
Journal
Biochemical and Biophysical Research Communications
Author(s)
Fasel N.J., Bernard M., Déglon N., Rousseaux M., Eisenberg R.J., Bron C., Cohen G.H.
ISSN
0006-291X (Print)
ISSN-L
0006-291X
Publication state
Published
Issued date
1991
Volume
178
Number
1
Pages
8-15
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
Structural definition of the receptors for neurotropic and angiogenic modulators such as fibroblast growth factors and related polypeptides will yield insight into the mechanisms that control early development, embryogenesis, organogenesis, wound repair and neovessel formation. We isolated 3 murine cDNAs encoding different binding domains of these receptors (flg). Comparison of these ectoplasmic portions showed that two of the forms corresponded to previously described murine molecules whereas the third one had a different ectoplasmic portion generated by specific changes in two regions. Interestingly, expression of this third form seems to be restricted in its tissue distribution. Such modifications could influence the ligand specificity of the different receptors and/or their binding affinity.
Keywords
Amino Acid Sequence, Animals, Antisense Elements (Genetics), Base Sequence, Cell Line, DNA/genetics, DNA/isolation & purification, Fibroblast Growth Factors/metabolism, Humans, L Cells (Cell Line)/metabolism, Mice, Molecular Sequence Data, Oligonucleotide Probes, Receptors, Cell Surface/genetics, Receptors, Fibroblast Growth Factor, Ribonuclease, Pancreatic, Sequence Homology, Nucleic Acid, Transcription, Genetic
Pubmed
Web of science
Create date
24/01/2008 15:02
Last modification date
20/08/2019 14:22
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