Association between left atrial phasic conduit function and early atrial fibrillation recurrence in patients undergoing electrical cardioversion.

Details

Serval ID
serval:BIB_662912C7637E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Association between left atrial phasic conduit function and early atrial fibrillation recurrence in patients undergoing electrical cardioversion.
Journal
Clinical research in cardiology
Author(s)
Degiovanni A., Boggio E., Prenna E., Sartori C., De Vecchi F., Marino P.N.
Working group(s)
From the Novara Atrial Fibrillation (NAIF) Study Group
Contributor(s)
Degiovanni A., Marino P.N.
ISSN
1861-0692 (Electronic)
ISSN-L
1861-0684
Publication state
Published
Issued date
04/2018
Peer-reviewed
Oui
Volume
107
Number
4
Pages
329-337
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Diastolic dysfunction promotes atrial fibrillation (AF) inducing left atrial (LA) remodeling, with chamber dilation and fibrosis. Predominance of LA phasic conduit (LAC) function should reflect not only chamber alterations but also underlying left ventricular (LV) filling impairment. Thus, LAC was tested as possible predictor of early AF relapse after electrical cardioversion (EC).
96 consecutive patients, who underwent EC for persistent non-valvular AF, were prospectively enrolled. Immediately after successful EC (3 h ± 15 min), an echocardiographic apical four-chamber view was acquired with transmitral velocities, annular tissue Doppler and simultaneous LV and LA three-dimensional full-volume datasets. Then, from LA-LV volumetric curves we computed LAC as: [(LV maximum - LV minimum) - (LA maximum - LA minimum) volume], expressed as % LV stroke volume. LA pump, immediately post-EC, was assumed and verified as being negligible. Sinus rhythm persistence at 1 month was checked with ECG-Holter monitoring.
At 1 month 62 patients were in sinus rhythm and 34 in AF. AF patients presented pre-EC higher E/é values (p = 0.012), no major LA volume differences (p = NS), but a stiffer LV cavity (p = 0.012) for a comparable LV capacitance (p = 0.461). Conduit contributed more (p < 0.001) to LV stroke volume in AF subpopulation. Multiple regression revealed LAC as the most significant AF predictor (p = 0.013), even after correction for biometric characteristics and pharmacotherapy (p = 0.008).
Our data suggest that LAC larger contribution to LV filling soon after EC reflects LA-LV stiffening, which skews atrioventricular interaction leading to AF perpetuation and makes conduit dominance a powerful predictor of early AF recurrence.

Keywords
Atrial fibrillation, Electrical cardioversion, Full-volume 3D echocardiography, Left atrial conduit function
Pubmed
Web of science
Open Access
Yes
Create date
17/01/2018 10:33
Last modification date
20/08/2019 14:22
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