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Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertension
Journal of the Renin-Angiotensin-Aldosterone System
Pharmacological treatment of hypertension is effective in preventing cardiovascular and renal complications. Calcium antagonists (CAs) and blockers of the renin-angiotensin system [angiotensin-converting enzyme (ACE) inhibitors and angiotensin II antagonists (ARBs)] are widely used today to initiate antihypertensive treatment but, when given as monotherapy, do not suffice in most patients to normalise blood pressure (BP). Combining a CA and either an ACE-inhibitor or an ARB considerably increases the antihypertensive efficacy, but not at the expense of a deterioration of tolerability. Several fixed-dose combinations are available (CA + ACE-inhibitors: amlodipine + benazepril, felodipine + ramipril, verapamil + trandolapril; CA + ARB: amlodipine + valsartan). They are expected not only to improve BP control, but also to facilitate long-term adherence with antihypertensive therapy, thereby providing maximal protection against the cardiovascular and renal damage caused by high BP.
administration & dosage , Adult , adverse effects , Aged , Angiotensin II , Angiotensin-Converting Enzyme Inhibitors , antagonists & inhibitors , Atenolol , blood , Blood Pressure , Calcium , Calcium Channel Blockers , complications , Drug Combinations , drug effects , drug therapy , Drug Therapy,Combination , Enzyme Inhibitors , Humans , Hypertension , Indoles , Middle Aged , Patients , Randomized Controlled Trials as Topic , Renin-Angiotensin System , Switzerland , Sympathetic Nervous System , therapeutic use , therapy , Verapamil
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