The transcription factor DBP affects circadian sleep consolidation and rhythmic EEG activity.

Details

Serval ID
serval:BIB_65EF510A732E
Type
Article: article from journal or magazin.
Collection
Publications
Title
The transcription factor DBP affects circadian sleep consolidation and rhythmic EEG activity.
Journal
Journal of Neuroscience
Author(s)
Franken P., Lopez-Molina L., Marcacci L., Schibler U., Tafti M.
ISSN
1529-2401[electronic]
Publication state
Published
Issued date
2000
Volume
20
Number
2
Pages
617-625
Language
english
Abstract
Albumin D-binding protein (DBP) is a PAR leucine zipper transcription factor that is expressed according to a robust circadian rhythm in the suprachiasmatic nuclei, harboring the circadian master clock, and in most peripheral tissues. Mice lacking DBP display a shorter circadian period in locomotor activity and are less active. Thus, although DBP is not essential for circadian rhythm generation, it does modulate important clock outputs. We studied the role of DBP in the circadian and homeostatic aspects of sleep regulation by comparing DBP deficient mice (dbp-/-) with their isogenic controls (dbp+/+) under light-dark (LD) and constant-dark (DD) baseline conditions, as well as after sleep loss. Whereas total sleep duration was similar in both genotypes, the amplitude of the circadian modulation of sleep time, as well as the consolidation of sleep episodes, was reduced in dbp-/- under both LD and DD conditions. Quantitative EEG analysis demonstrated a marked reduction in the amplitude of the sleep-wake-dependent changes in slow-wave sleep delta power and an increase in hippocampal theta peak frequency in dbp-/- mice. The sleep deprivation-induced compensatory rebound of EEG delta power was similar in both genotypes. In contrast, the rebound in paradoxical sleep was significant in dbp+/+ mice only. It is concluded that the transcriptional regulatory protein DBP modulates circadian and homeostatic aspects of sleep regulation.
Keywords
Animals, Circadian Rhythm, DNA-Binding Proteins, Darkness, Delta Rhythm, Electroencephalography, Electromyography, Leucine Zippers, Light, Mice, Mice, Knockout, Motor Activity, Photoperiod, Reference Values, Sleep, Transcription Factors
Pubmed
Web of science
Create date
24/01/2008 15:55
Last modification date
20/08/2019 14:21
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