A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis.

Rammaert, B.; Bochud, P.Y.; Brunel, A.S.; Wojtowicz, A.; Candon, S.; Gallego Hernanz, M.P.; Lortholary, O.

doi:10.1093/ofid/ofad078

A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis.

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Serval ID

serval:BIB_65C3E7B237A1

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis.

Journal

Open forum infectious diseases

Author(s)

Rammaert B., Bochud P.Y., Brunel A.S., Wojtowicz A., Candon S., Gallego Hernanz M.P., Lortholary O.

ISSN

2328-8957 (Print)

ISSN-L

2328-8957

Publication state

Published

Issued date

03/2023

Peer-reviewed

Oui

Volume

Number

Pages

ofad078

Language

english

Notes

Publication types: Journal Article
Publication Status: epublish

Abstract

We investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and a prospective matched-control study. We found that an SNP located in interleukin-1B at rs1143627 was significantly associated with the risk of developing IRIS-CDC.

Keywords

Candida spp, IL-1B, cytokines, genetic polymorphism, immune inflammatory reconstitution syndrome, invasive fungal diseases

OAI-PMH

oai:serval.unil.ch:BIB_65C3E7B237A1

DOI

10.1093/ofid/ofad078

Pubmed

36879623

Web of science

001012150100005

Open Access

Yes