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Rearrangement by chromosomal inversion in the T cell receptor gamma locus in a murine alpha beta T cell clone
Journal Article --- Old month value: Dec
Analyzing the T-cell receptor (TCR) repertoire of T lymphocytes specific for minor histocompatibility antigens, we isolated a TCR-alpha beta bearing T cell clone, TGVH9, which also expresses three different TCR-gamma mRNA. The sequences of these messengers indicate that one of them results from the rearrangement of V gamma 1 and J gamma 2 genes. Since these two segments are in inverted genomic transcriptional orientation, the joining of V gamma 1 to J gamma 2 occurred by chromosomal inversion. This mechanism, which was previously reported in TCR-beta and TCR-delta loci, can thus also occur to enlarge the diversity of the TCR-gamma repertoire.
Amino Acid Sequence Animals Base Sequence Clone Cells Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor/*genetics Gene Rearrangement, beta-Chain T-Cell Antigen Receptor/*genetics *Inversion, Chromosome Mice Mice, Inbred DBA Molecular Sequence Data Receptors, Antigen, T-Cell, alpha-beta/*genetics Receptors, Antigen, T-Cell, gamma-delta/*genetics
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