Influence of IFNL3/4 Polymorphisms on the Incidence of Cytomegalovirus Infection After Solid-Organ Transplantation.

Détails

Ressource 1Télécharger: serval:BIB_653026F3E5A8.P001 (331.14 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_653026F3E5A8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Influence of IFNL3/4 Polymorphisms on the Incidence of Cytomegalovirus Infection After Solid-Organ Transplantation.
Périodique
Journal of Infectious Diseases
Auteur(s)
Manuel O., Wójtowicz A., Bibert S., Mueller N.J., van Delden C., Hirsch H.H., Steiger J., Stern M., Egli A., Garzoni C., Binet I., Weisser M., Berger C., Cusini A., Meylan P., Pascual M., Bochud P.Y.
Collaborateur(s)
Swiss Transplant Cohort Study (STCS), Swiss Transplant Cohort Study STCS
Contributeur(s)
Binet I., De Geest S., van Delden C., Hofbauer G., Huynh-Do U., Koller M., Lovis C., Manuel O., Meylan P., Mueller Nj., Pascual M., Schaub S., Steiger J.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Statut éditorial
Publié
Date de publication
2015
Volume
211
Numéro
6
Pages
906-914
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND: Polymorphisms in IFNL3 and IFNL4, the genes encoding interferon λ3 and interferon λ4, respectively, have been associated with reduced hepatitis C virus clearance. We explored the role of such polymorphisms on the incidence of cytomegalovirus (CMV) infection in solid-organ transplant recipients.
METHODS: White patients participating in the Swiss Transplant Cohort Study in 2008-2011 were included. A novel functional TT/-G polymorphism (rs368234815) in the CpG region upstream of IFNL3 was investigated.
RESULTS: A total of 840 solid-organ transplant recipients at risk for CMV infection were included, among whom 373 (44%) received antiviral prophylaxis. The 12-month cumulative incidence of CMV replication and disease were 0.44 and 0.08 cases, respectively. Patient homozygous for the minor rs368234815 allele (-G/-G) tended to have a higher cumulative incidence of CMV replication (subdistribution hazard ratio [SHR], 1.30 [95% confidence interval {CI}, .97-1.74]; P = .07), compared with other patients (TT/TT or TT/-G). The association was significant among patients followed by a preemptive approach (SHR, 1.46 [95% CI, 1.01-2.12]; P = .047), especially in patients receiving an organ from a seropositive donor (SHR, 1.92 [95% CI, 1.30-2.85]; P = .001), but not among those who received antiviral prophylaxis (SHR, 1.13 [95% CI, .70-1.83]; P = .6). These associations remained significant in multivariate competing risk regression models.
CONCLUSIONS: Polymorphisms in the IFNL3/4 region influence susceptibility to CMV replication in solid-organ transplant recipients, particularly in patients not receiving antiviral prophylaxis.
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/04/2015 19:26
Dernière modification de la notice
25/09/2019 6:09
Données d'usage