Molecular mechanisms involved in the activation and regulation of the alpha 1-adrenergic receptor subtypes.

Détails

ID Serval
serval:BIB_6514CF6C93DD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Molecular mechanisms involved in the activation and regulation of the alpha 1-adrenergic receptor subtypes.
Périodique
Farmaco
Auteur(s)
Cotecchia S., Scheer A., Diviani D., Fanelli F., De Benedetti P.G.
ISSN
0014-827X (Print)
ISSN-L
0014-827X
Statut éditorial
Publié
Date de publication
1998
Volume
53
Numéro
4
Pages
273-277
Langue
anglais
Résumé
The adrenergic receptors (ARs) belong to the superfamily of membrane-bound G protein coupled receptors (GPCRs). Our investigation has focused on the structure-function relationship of the alpha 1b-AR subtype used as the model system for other GPCRs. Site-directed mutagenesis studies have elucidated the structural domains of the alpha 1b-AR involved in ligand binding, G protein coupling or desensitization. In addition, a combined approach using site-directed mutagenesis and molecular dynamics analysis of the alpha 1b-AR has provided information about the potential mechanisms underlying the activation process of the receptor, i.e. its transition from the 'inactive' to the 'active' conformation.
Mots-clé
Amino Acid Sequence, Animals, GTP-Binding Proteins/physiology, Humans, Molecular Sequence Data, Mutagenesis, Site-Directed, Receptors, Adrenergic, alpha-1/chemistry, Receptors, Adrenergic, alpha-1/classification, Structure-Activity Relationship
Pubmed
Web of science
Création de la notice
24/01/2008 11:05
Dernière modification de la notice
20/08/2019 14:21
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