Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Molecular mechanisms involved in the activation and regulation of the alpha 1-adrenergic receptor subtypes.
The adrenergic receptors (ARs) belong to the superfamily of membrane-bound G protein coupled receptors (GPCRs). Our investigation has focused on the structure-function relationship of the alpha 1b-AR subtype used as the model system for other GPCRs. Site-directed mutagenesis studies have elucidated the structural domains of the alpha 1b-AR involved in ligand binding, G protein coupling or desensitization. In addition, a combined approach using site-directed mutagenesis and molecular dynamics analysis of the alpha 1b-AR has provided information about the potential mechanisms underlying the activation process of the receptor, i.e. its transition from the 'inactive' to the 'active' conformation.
Amino Acid Sequence, Animals, GTP-Binding Proteins/physiology, Humans, Molecular Sequence Data, Mutagenesis, Site-Directed, Receptors, Adrenergic, alpha-1/chemistry, Receptors, Adrenergic, alpha-1/classification, Structure-Activity Relationship
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