Effective connectivity inferred from fMRI transition dynamics during movie viewing points to a balanced reconfiguration of cortical interactions.

Détails

ID Serval
serval:BIB_64FAF9617DF0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Effective connectivity inferred from fMRI transition dynamics during movie viewing points to a balanced reconfiguration of cortical interactions.
Périodique
NeuroImage
Auteur(s)
Gilson M., Deco G., Friston K.J., Hagmann P., Mantini D., Betti V., Romani G.L., Corbetta M.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
15/10/2018
Peer-reviewed
Oui
Volume
180
Numéro
Pt B
Pages
534-546
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Our behavior entails a flexible and context-sensitive interplay between brain areas to integrate information according to goal-directed requirements. However, the neural mechanisms governing the entrainment of functionally specialized brain areas remain poorly understood. In particular, the question arises whether observed changes in the regional activity for different cognitive conditions are explained by modifications of the inputs to the brain or its connectivity? We observe that transitions of fMRI activity between areas convey information about the tasks performed by 19 subjects, watching a movie versus a black screen (rest). We use a model-based framework that explains this spatiotemporal functional connectivity pattern by the local variability for 66 cortical regions and the network effective connectivity between them. We find that, among the estimated model parameters, movie viewing affects to a larger extent the local activity, which we interpret as extrinsic changes related to the increased stimulus load. However, detailed changes in the effective connectivity preserve a balance in the propagating activity and select specific pathways such that high-level brain regions integrate visual and auditory information, in particular boosting the communication between the two brain hemispheres. These findings speak to a dynamic coordination underlying the functional integration in the brain.
Mots-clé
Acoustic Stimulation, Adult, Auditory Perception/physiology, Brain/physiology, Brain Mapping/methods, Female, Humans, Image Processing, Computer-Assisted/methods, Magnetic Resonance Imaging/methods, Male, Models, Neurological, Motion Pictures, Nerve Net/physiology, Neural Pathways/physiology, Photic Stimulation, Rest/physiology, Visual Perception/physiology, Young Adult
Pubmed
Web of science
Création de la notice
26/10/2017 17:04
Dernière modification de la notice
20/08/2019 15:21
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