Cellular Composition and Contribution of Tertiary Lymphoid Structures to Tumor Immune Infiltration and Modulation by Radiation Therapy.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_64E7EAD7D9CF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cellular Composition and Contribution of Tertiary Lymphoid Structures to Tumor Immune Infiltration and Modulation by Radiation Therapy.
Périodique
Frontiers in oncology
Auteur(s)
Boivin G., Kalambaden P., Faget J., Rusakiewicz S., Montay-Gruel P., Meylan E., Bourhis J., Lesec G., Vozenin M.C.
ISSN
2234-943X (Print)
ISSN-L
2234-943X
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
8
Pages
256
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Immune-based anti-cancer strategies combined with radiation therapy (RT) are actively being investigated but many questions remain, such as the ideal treatment scheme and whether a potent immune response can be generated both locally and systemically. In this context, tumor-associated tertiary lymphoid structures (TLS) have become a subject of research. While TLS are present in several types of cancer with strong similarities, they are especially relevant in medullary breast carcinoma (MBC). This suggests that MBC patients are ideally suited for investigating this question and may benefit from adapted therapeutic options. As RT is a corner-stone of MBC treatment, investigating interactions between RT and TLS composition is also clinically relevant. We thus first characterized the lymphoid structures associated with MBC in a patient case report and demonstrated that they closely resemble the TLS observed in a genetical mouse model. In this model, we quantitatively and qualitatively investigated the cellular composition of the tumor-associated TLS. Finally, we investigated TLS regulation after hypo-fractionated RT and showed that RT induced their acute and transient depletion, followed by a restoration phase. This study is the first work to bring a comprehensive and timely characterization of tumor-associated TLS in basal conditions and after RT. It highlights cellular targets (i.e., Tregs) that could be selectively modulated in subsequent studies to optimize anti-tumor immune response. The study of TLS modulation is worth further investigation in the context of RT and personalized medicine.
Mots-clé
KP model, medullary breast carcinoma, microenvironment, radiation therapy, tertiary lymphoid structures
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/07/2018 12:52
Dernière modification de la notice
20/08/2019 14:21
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