Development of neuronal markers in aggregating fetal rat telencephalon cells cultured in the presence of triiodothyronine.

Details

Serval ID
serval:BIB_64CBE010516F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Development of neuronal markers in aggregating fetal rat telencephalon cells cultured in the presence of triiodothyronine.
Journal
International Journal of Developmental Neuroscience
Author(s)
Jørgensen O.S., Honegger P.
ISSN
0736-5748 (Print)
ISSN-L
0736-5748
Publication state
Published
Issued date
1986
Volume
4
Number
6
Pages
519-524
Language
english
Abstract
The concentrations of the general neuronal markers D2-protein (N-CAM), D3-protein and neuron specific enolase (NSE) in reaggregating cultures of fetal rat telencephalon cells were affected by the presence of 30 nM triiodothyronine in the defined culture medium. The extent of normal developmental changes were enhanced by triiodothyronine, as demonstrated by crossed immunoelectrophoresis. From 13 to 19 days in culture, the concentration of D2-protein decreased, and the concentrations of both D3-protein and NSE increased. Nerve growth factor (NGF) was without effect on the development of these general neuronal markers. However, as shown previously both triiodothyronine and NGF increased the activity of choline acetyltransferase, a marker for cholinergic neurons. The results suggest an enhanced overall differentiation of several types of telencephalon neurons in the presence of triiodothyronine, and a specific stimulation of cholinergic telencephalon neurons by NGF.
Keywords
Animals, Antigens, Surface/metabolism, Cell Adhesion Molecules, Cell Aggregation/drug effects, Cells, Cultured, Fetus, Phosphopyruvate Hydratase/metabolism, Rats, Telencephalon/cytology, Telencephalon/drug effects, Triiodothyronine/pharmacology
Pubmed
Web of science
Create date
24/01/2008 13:12
Last modification date
20/08/2019 14:21
Usage data