Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls.

Details

Serval ID
serval:BIB_6468D04BFF3B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls.
Journal
Journal of cystic fibrosis
Author(s)
Korten I., Liechti M., Singer F., Hafen G., Rochat I., Anagnostopoulou P., Müller-Suter D., Usemann J., Moeller A., Frey U., Latzin P., Casaulta C.
Working group(s)
SCILD and BILD study group
ISSN
1873-5010 (Electronic)
ISSN-L
1569-1993
Publication state
Published
Issued date
01/2018
Peer-reviewed
Oui
Volume
17
Number
1
Pages
105-108
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Exhaled nitric oxide (FE <sub>NO</sub> ) is a well-known, non-invasive airway biomarker. In patients with Cystic Fibrosis (CF) FE <sub>NO</sub> is decreased. To understand if reduced FE <sub>NO</sub> is primary related to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction or an epiphenomenon of chronic inflammation, we measured FE <sub>NO</sub> in 34 infants with CF prior to clinical symptoms and in 68 healthy controls. FE <sub>NO</sub> was lower in CF compared to controls (p=0.0006) and the effect was more pronounced in CF infants without residual CFTR function (p<0.0001). This suggests that FE <sub>NO</sub> is reduced in CF early in life, possibly associated with underlying CFTR dysfunction.
Keywords
Asymptomatic Diseases, Biomarkers/analysis, Biomarkers/metabolism, Breath Tests/methods, Cohort Studies, Cystic Fibrosis/diagnosis, Cystic Fibrosis/metabolism, Cystic Fibrosis Transmembrane Conductance Regulator/metabolism, Exhalation, Female, Humans, Infant, Inflammation/metabolism, Male, Nitric Oxide/analysis, Nitric Oxide/metabolism, Switzerland
Pubmed
Web of science
Create date
10/08/2017 12:17
Last modification date
20/08/2019 14:20
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