Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy.

Détails

ID Serval
serval:BIB_644807C95340
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy.
Périodique
Annals of Thoracic Surgery
Auteur(s)
Rotas I., Cito G., Letovanec I., Christodoulou M., Perentes J.Y.
ISSN
1552-6259 (Electronic)
ISSN-L
0003-4975
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
101
Numéro
2
Pages
e51-e53
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
Hypertrophic osteoarthrpathy (HO) is a rare paraneoplasic syndrome associated with non-small cell lung cancer (NSCLC). The pathophysiology of HO is unknown but was recently related to enhanced levels of urine prostaglandin E2 (PGE2). Here, we report the case of a patient that presented HO in association with a resectable left upper lobe NSCLC. Following surgery and adjuvant chemotherapy, HO resolved and did not recur with development of a brain metastasis 1 year later. Interestingly, tumor cyclooxygenase-2, an enzyme responsible the synthesis of PGE2, was expressed in the primary tumor but not in the resected metastasis.
Mots-clé
Aged, Carcinoma, Non-Small-Cell Lung/metabolism, Cyclooxygenase 2/biosynthesis, Humans, Lung Neoplasms/metabolism, Male, Osteoarthropathy, Secondary Hypertrophic/metabolism, Paraneoplastic Syndromes/metabolism
Pubmed
Web of science
Création de la notice
20/01/2016 13:25
Dernière modification de la notice
20/08/2019 15:20
Données d'usage