Prediction of infant drug exposure through breastfeeding: population PK modeling and simulation of fluoxetine

Détails

ID Serval
serval:BIB_6443F343035E
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
Prediction of infant drug exposure through breastfeeding: population PK modeling and simulation of fluoxetine
Titre de la conférence
110th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics
Auteur(s)
Garcia-Bournissen F., Panchaud A., Csajka C., Kristensen J.H.., Taddio A, Ilett K.F., Begg E.J., Ito S.
Adresse
National Harbor, Maryland, United-States, March 18-21, 2009
ISBN
0009-9236
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
85
Série
Clinical Pharmacology and Therapeutics
Pages
S1
Langue
anglais
Résumé
BACKGROUND: Risks of significant infant drug exposurethrough breastmilk are poorly defined for many drugs, and largescalepopulation data are lacking. We used population pharmacokinetics(PK) modeling to predict fluoxetine exposure levels ofinfants via mother's milk in a simulated population of 1000 motherinfantpairs.METHODS: Using our original data on fluoxetine PK of 25breastfeeding women, a population PK model was developed withNONMEM and parameters, including milk concentrations, wereestimated. An exponential distribution model was used to account forindividual variation. Simulation random and distribution-constrainedassignment of doses, dosing time, feeding intervals and milk volumewas conducted to generate 1000 mother-infant pairs with characteristicssuch as the steady-state serum concentrations (Css) and infantdose relative to the maternal weight-adjusted dose (relative infantdose: RID). Full bioavailability and a conservative point estimate of1-month-old infant CYP2D6 activity to be 20% of the adult value(adjusted by weigth) according to a recent study, were assumed forinfant Css calculations.RESULTS: A linear 2-compartment model was selected as thebest model. Derived parameters, including milk-to-plasma ratios(mean: 0.66; SD: 0.34; range, 0 - 1.1) were consistent with the valuesreported in the literature. The estimated RID was below 10% in >95%of infants. The model predicted median infant-mother Css ratio was0.096 (range 0.035 - 0.25); literature reported mean was 0.07 (range0-0.59). Moreover, the predicted incidence of infant-mother Css ratioof >0.2 was less than 1%.CONCLUSION: Our in silico model prediction is consistent withclinical observations, suggesting that substantial systemic fluoxetineexposure in infants through human milk is rare, but further analysisshould include active metabolites. Our approach may be valid forother drugs. [supported by CIHR and Swiss National Science Foundation(SNSF)]
Web of science
Création de la notice
21/06/2010 15:47
Dernière modification de la notice
20/08/2019 14:20
Données d'usage