Chiasmatic infiltration secondary to late malignant transformation of retinoma.

Détails

ID Serval
serval:BIB_64420F18E8CD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Chiasmatic infiltration secondary to late malignant transformation of retinoma.
Périodique
Ophthalmic Genetics
Auteur(s)
Mataftsi A., Zografos L., Balmer A., Uffer S., Stupp R., Janzer R.C., Pica A., Schorderet D.F., Munier F.L.
ISSN
1744-5094 (Electronic)
ISSN-L
1381-6810
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
33
Numéro
3
Pages
155-158
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
Résumé
PURPOSE: To report the lethal course of malignant transformation of retinoma in an adult.
METHODS: Case report. A 40-year-old patient presented with retinoma in his right eye and retinoblastoma in his left eye. Enucleation was recommended but refused and the patient received whole eye radiotherapy elsewhere. Five years later he presented again, with temporal hemianopsia of the left eye secondary to chiasmatic invasion.
RESULTS: Diagnosis of retinoblastoma infiltration was confirmed by stereotactic biopsy of the chiasmatic lesion. Treatment with intravenous and intrathecal chemotherapy led to partial remission, and was followed by stereotactic irradiation of the chiasmatic mass and right optic nerve. The left eye was enucleated. Death occurred one year later due to cerebrospinal fluid metastases.
CONCLUSION: Extraocular extension of retinoblastoma diagnosed in adulthood has never, to our knowledge, been reported. This case stresses the importance of lifelong retinoma monitoring and the necessity for radical treatment in the event of malignant transformation.
Mots-clé
Adult, Cell Transformation, Neoplastic/pathology, Eye Enucleation, Humans, Magnetic Resonance Imaging, Male, Neoplasm Invasiveness/pathology, Optic Chiasm/pathology, Optic Nerve Neoplasms/pathology, Precancerous Conditions/pathology, Retinal Neoplasms/genetics, Retinal Neoplasms/pathology, Retinoblastoma/genetics, Retinoblastoma/pathology, Retinoblastoma Protein/genetics, Tomography, X-Ray Computed
Pubmed
Web of science
Création de la notice
24/05/2011 14:42
Dernière modification de la notice
20/08/2019 14:20
Données d'usage