Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?

Détails

ID Serval
serval:BIB_643866D47BDE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?
Périodique
Trends in cancer
Auteur(s)
Özdemir B.C., Dotto G.P.
ISSN
2405-8025 (Electronic)
ISSN-L
2405-8025
Statut éditorial
Publié
Date de publication
03/2017
Peer-reviewed
Oui
Volume
3
Numéro
3
Pages
181-197
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Epidemiological studies point to race as a determining factor in cancer susceptibility. In US registries recording cancer incidence and survival by race (distinguishing 'black versus white'), individuals of African ancestry have a globally increased risk of malignancies compared with Caucasians and Asian Americans. Differences in socioeconomic status and health-care access play a key role. However, the lesser disease susceptibility of Hispanic populations with comparable lifestyles and socioeconomic status as African Americans (Hispanic paradox) points to the concomitant importance of genetic determinants. Here, we overview the molecular basis of racial disparity in cancer susceptibility ranging from genetic polymorphisms and cancer-driver gene mutations to obesity, chronic inflammation, and immune responses. We discuss implications for race-adapted cancer screening programs and clinical trials to reduce disparities in cancer burden.
Mots-clé
Asian Americans/genetics, Continental Population Groups/genetics, European Continental Ancestry Group/genetics, Genetic Predisposition to Disease, Healthcare Disparities, Hispanic Americans/genetics, Humans, Neoplasms/epidemiology, Neoplasms/genetics, Neoplasms/pathology, Social Class
Pubmed
Web of science
Création de la notice
10/08/2017 9:52
Dernière modification de la notice
20/08/2019 14:20
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