Article: article from journal or magazin.
Transient uptake and storage of serotonin in developing thalamic neurons
Journal Article --- Old month value: Nov
Serotonin (5-HT) has been shown to affect the development and patterning of the mouse barrelfield. We show that the dense transient 5-HT innervation of the somatosensory, visual, and auditory cortices originates in the thalamus rather than in the raphe: 5-HT is detected in thalamocortical fibers and most 5-HT cortical labeling disappears after thalamic lesions. Thalamic neurons do not synthesize 5-HT but take up exogenous 5-HT through 5-HT high affinity uptake sites located on thalamocortical axons and terminals. 3H-5-HT injected into the cortex is retrogradely transported to thalamic neurons. In situ hybridization shows a transient expression of the genes encoding the serotonin transporter and the vesicular monoamine transporter in thalamic sensory neurons. In these glutamatergic neurons, internalized 5-HT might thus be stored and used as a "borrowed transmitter" for extraneuronal signaling or could exert an intraneuronal control on thalamic maturation.
Age Factors Animals Antibody Specificity Biological Transport/physiology Carrier Proteins/analysis/genetics/metabolism Cerebral Cortex/cytology/metabolism Gene Expression/physiology Immunohistochemistry In Situ Hybridization Membrane Glycoproteins/analysis/genetics/metabolism *Membrane Transport Proteins Mice Mice, Inbred C57BL *Nerve Tissue Proteins Neurons, Afferent/chemistry/*metabolism *Neuropeptides Neurotransmitter Agents/analysis/genetics/metabolism RNA, Messenger/analysis Rats Rats, Sprague-Dawley Serotonin/biosynthesis/immunology/*pharmacokinetics Serotonin Plasma Membrane Transport Proteins Synaptic Vesicles/metabolism Thalamus/*cytology/growth & development/metabolism Time Factors Tritium/diagnostic use Vesicular Biogenic Amine Transport Proteins Vesicular Monoamine Transport Proteins
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