A controlled trial of individually-adapted short-course chemotherapy versus two-year scheme in original treatment of pulmonary tuberculosis. Report after a five-year follow-up

Details

Serval ID
serval:BIB_64044EE1AD72
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A controlled trial of individually-adapted short-course chemotherapy versus two-year scheme in original treatment of pulmonary tuberculosis. Report after a five-year follow-up
Journal
Chest
Author(s)
Favez  G., Leuenberger  P.
ISSN
0012-3692 (Print)
Publication state
Published
Issued date
10/1982
Volume
82
Number
4
Pages
426-9
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Oct
Abstract
Patients with culture-positive pulmonary tuberculosis were allocated at random into two groups for a three-phase regimen in original course chemotherapy. The first group was given rifampicin (RMP) plus isoniazid (INH) plus ethambutol until sensitivity tests were completed, then RMP plus INH until culture conversion, thereafter INH alone for four months. The second group received the same drugs until obtaining culture conversion, thereafter IHN alone for a period lasting two years after onset of chemotherapy. One hundred sixty-eight patients were available for the final assessment after a five-year follow-up after culture conversion. Two bacteriologic relapses occurred among the two-year scheme patients, none in the short-course patients.
Keywords
Adolescent Adult Aged Antitubercular Agents/*administration & dosage Clinical Trials Drug Therapy, Combination Ethambutol/administration & dosage Female Humans Isoniazid/administration & dosage Male Middle Aged Mycobacterium tuberculosis/isolation & purification Rifampin/administration & dosage Time Factors Tuberculosis, Pulmonary/*drug therapy/microbiology
Pubmed
Web of science
Create date
25/01/2008 9:50
Last modification date
20/08/2019 14:20
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