Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Super-enhancer lncs to cardiovascular development and disease.
BBA - Molecular Cell Research
7 Pt B
Cardiac development, function and pathological remodelling in response to stress depend on the dynamic control of tissue specific gene expression by distant acting transcriptional enhancers. Recently, super-enhancers (SEs), also known as stretch or large enhancer clusters, are emerging as sentinel regulators within the gene regulatory networks that underpin cellular functions. It is becoming increasingly evident that long noncoding RNAs (lncRNAs) associated with these sequences play fundamental roles for enhancer activity and the regulation of the gene programs hardwired by them. Here, we review this emerging landscape, focusing on the roles of SEs and their derived lncRNAs in cardiovascular development and disease. We propose that exploration of this genomic landscape could provide novel therapeutic targets and approaches for the amelioration of cardiovascular disease. Ultimately we envisage a future of ncRNA therapeutics targeting the SE landscape to alleviate cardiovascular disease. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.
Animals, Cardiovascular Diseases/genetics, Cardiovascular Diseases/metabolism, Cardiovascular System/embryology, Cardiovascular System/metabolism, Enhancer Elements, Genetic, Gene Expression Regulation, Developmental, Genetic Predisposition to Disease, Genomics/methods, Humans, Morphogenesis, Phenotype, RNA, Long Noncoding/genetics, RNA, Long Noncoding/metabolism, Risk Factors
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