Oxytocin selectively gates fear responses through distinct outputs from the central amygdala.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_63636CF05C9E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Oxytocin selectively gates fear responses through distinct outputs from the central amygdala.
Périodique
Science
Auteur(s)
Viviani D., Charlet A., van den Burg E., Robinet C., Hurni N., Abatis M., Magara F., Stoop R.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
333
Numéro
6038
Pages
104-107
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular response. Thus, neuropeptidergic signaling can modulate the CeA outputs through separate neuronal circuits and thereby individually steer the various aspects of the fear response.
Mots-clé
Amygdala/physiology, Animals, Bombesin/pharmacology, Brain Stem/physiology, Conditioning (Psychology), Fear/physiology, Female, GABA-A Receptor Agonists/pharmacology, Heart Rate/drug effects, Hypothalamus/physiology, Male, Muscimol/pharmacology, Neural Inhibition, Neural Pathways/physiology, Neurons/physiology, Oxytocin/agonists, Oxytocin/analogs & derivatives, Patch-Clamp Techniques, Periaqueductal Gray/physiology, Rats, Rats, Sprague-Dawley
Pubmed
Web of science
Création de la notice
13/07/2011 9:57
Dernière modification de la notice
20/08/2019 14:20
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