HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_62C12F4E0858
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection.
Journal
BMC immunology
Author(s)
Obuku A.E., Lugemwa J.K., Abaasa A., Joloba M., Ding S., Pollara J., Ferrari G., Harari A., Pantaleo G., Kaleebu P.
ISSN
1471-2172 (Electronic)
ISSN-L
1471-2172
Publication state
Published
Issued date
29/08/2023
Peer-reviewed
Oui
Volume
24
Number
1
Pages
25
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Fishing communities surrounding Lake Victoria in Uganda have HIV prevalence of 28% and incidence rates of 5 per 100 person years. More than 50% of the local fishermen are infected with Schistosoma mansoni (S. mansoni). We investigated the role of S. mansoni coinfection as a possible modifier of immune responses against HIV. Using polychromatic flow cytometry and Gran-ToxiLux assays, HIV specific responses, T cell phenotypes, antibody-dependent cell-mediated cytotoxic (ADCC) potency and titres were compared between participants with HIV-S. mansoni coinfection and participants with HIV infection alone.
S. mansoni coinfection was associated with a modified pattern of anti-HIV responses, including lower frequency of bifunctional (IFNγ + IL-2 - TNF-α+) CD4 T cells, higher overall CD4 T cell activation and lower HIV ADCC antibody titres, compared to participants with HIV alone.
These results support the hypothesis that S. mansoni infection affects T cell and antibody responses to HIV in coinfected individuals.
Keywords
Animals, Antibodies, Coinfection, HIV Infections/complications, HIV Infections/epidemiology, Schistosoma mansoni, Schistosomiasis/complications, Schistosomiasis/epidemiology, Down modulation, HIV-1, Immune responses, Schistosomiasis
Pubmed
Web of science
Open Access
Yes
Create date
19/09/2023 11:57
Last modification date
25/01/2024 7:37
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