HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection.
Details
Serval ID
serval:BIB_62C12F4E0858
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection.
Journal
BMC immunology
ISSN
1471-2172 (Electronic)
ISSN-L
1471-2172
Publication state
Published
Issued date
29/08/2023
Peer-reviewed
Oui
Volume
24
Number
1
Pages
25
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Fishing communities surrounding Lake Victoria in Uganda have HIV prevalence of 28% and incidence rates of 5 per 100 person years. More than 50% of the local fishermen are infected with Schistosoma mansoni (S. mansoni). We investigated the role of S. mansoni coinfection as a possible modifier of immune responses against HIV. Using polychromatic flow cytometry and Gran-ToxiLux assays, HIV specific responses, T cell phenotypes, antibody-dependent cell-mediated cytotoxic (ADCC) potency and titres were compared between participants with HIV-S. mansoni coinfection and participants with HIV infection alone.
S. mansoni coinfection was associated with a modified pattern of anti-HIV responses, including lower frequency of bifunctional (IFNγ + IL-2 - TNF-α+) CD4 T cells, higher overall CD4 T cell activation and lower HIV ADCC antibody titres, compared to participants with HIV alone.
These results support the hypothesis that S. mansoni infection affects T cell and antibody responses to HIV in coinfected individuals.
S. mansoni coinfection was associated with a modified pattern of anti-HIV responses, including lower frequency of bifunctional (IFNγ + IL-2 - TNF-α+) CD4 T cells, higher overall CD4 T cell activation and lower HIV ADCC antibody titres, compared to participants with HIV alone.
These results support the hypothesis that S. mansoni infection affects T cell and antibody responses to HIV in coinfected individuals.
Keywords
Animals, Antibodies, Coinfection, HIV Infections/complications, HIV Infections/epidemiology, Schistosoma mansoni, Schistosomiasis/complications, Schistosomiasis/epidemiology, Down modulation, HIV-1, Immune responses, Schistosomiasis
Pubmed
Web of science
Open Access
Yes
Create date
19/09/2023 11:57
Last modification date
25/01/2024 7:37