Sequential hormonal supplementation with vaginal estradiol and progesterone gel corrects the effect of clomiphene on the endometrium in oligo-ovulatory women

Details

Serval ID
serval:BIB_6297E87B218E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Sequential hormonal supplementation with vaginal estradiol and progesterone gel corrects the effect of clomiphene on the endometrium in oligo-ovulatory women
Journal
Human Reproduction
Author(s)
Elkind-Hirsch  K. E., Phillips  K., Bello  S. M., McNicho  M., de Ziegler  D.
ISSN
0268-1161
Publication state
Published
Issued date
02/2002
Peer-reviewed
Oui
Volume
17
Number
2
Pages
295-8
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
BACKGROUND: We investigated the possibility of correcting the endometrial alterations induced with clomiphene citrate (CC) by vaginal hormonal supplementation (HS) with estradiol (E2) and progesterone gel. METHODS: Oligo-ovulatory women were prospectively randomized into four groups receiving either 50 mg (groups 1 and 2) or 100 mg (groups 3 and 4) of CC from cycle day 3-8. Groups 2 and 4 also received vaginal E2 cream 0.1 mg twice daily from day 8 until the LH surge and vaginal progesterone gel, starting 3 days after ovulation. All participants had an endometrial biopsy performed 10 +/- 1 days after ovulation. RESULTS: All biopsies in the HS groups (2 and 4) showed complete predecidual changes, and were 'in-phase' with findings normally made 10 days post-ovulation (+/- 2 days of clinical dating). However, without HS (groups 1 and 3), only 4/6 and 3/6 biopsies showed predecidual changes in women receiving 50 and 100 mg of CC. CONCLUSION: The addition of vaginal E2 and progesterone to CC ovulation induction regimens normalizes the alterations in endometrial morphology. Hormonal treatment combining vaginal E2 and progesterone may improve endometrial receptivity in CC cycles and ultimately yield higher pregnancy rates.
Keywords
Administration, Intravaginal Adult Biopsy Endometrium/*drug effects/pathology Estradiol/*administration & dosage/therapeutic use Female Gels Humans Luteinizing Hormone/blood Ovulation/*drug effects Ovulation Induction/methods Progesterone/*administration & dosage/therapeutic use Prospective Studies Single-Blind Method Stromal Cells/pathology Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
28/02/2008 11:37
Last modification date
20/08/2019 14:19
Usage data