Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Immunosuppresseurs: usages systémiques et neurologiques [Systemic and neurological uses of immunosuppressive agents].
Revue Médicale Suisse
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish. PDF type: Mise au point
Involvement of the central or peripheral nervous system, frequently present in systemic inflammatory immune disorders, has to be considered a severe threat and requires aggressive immunosuppressive treatment to achieve rapid remission. This is usually obtained with high-dose systemic corticosteroids combined with cyclophosphamide. Once remission is obtained, immunosuppressive agents with a more favorable safety profile are needed to exert a corticosteroid-sparing effect and minimize adverse events. New therapeutic approaches are currently developed to treat autoimmune diseases, mostly linked to the definition of new indications for biological agents such as TNF-alpha antagonists and rituximab.
Antibodies, Monoclonal/therapeutic use, B-Lymphocytes/immunology, Humans, Immunosuppressive Agents/therapeutic use, Nervous System Diseases/drug therapy, Tumor Necrosis Factor-alpha/antagonists & inhibitors
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