Imaging of neuroendocrine tumors of the pancreas.

Details

Serval ID
serval:BIB_62749879807E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Imaging of neuroendocrine tumors of the pancreas.
Journal
Diagnostic and interventional imaging
Author(s)
Dromain C., Déandréis D., Scoazec J.Y., Goere D., Ducreux M., Baudin E., Tselikas L.
ISSN
2211-5684 (Electronic)
ISSN-L
2211-5684
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
97
Number
12
Pages
1241-1257
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish

Abstract
Pancreatic neuroendocrine tumors (PNETs) are rare and represent a heterogeneous disease. PNET can be functioning or non-functioning with different clinical presentations and different prognosis based on WHO and pTNM classifications. The role of imaging includes the localization of small functioning tumor, differentiation of these tumors from adenocarcinoma, identification of signs of malignancy and evaluation of extent. PNETs have a broad spectrum of appearance. On CT and MRI, most of functioning PNETs are well defined small tumors with intense and homogeneous enhancement on arterial and portal phases. However, some PNETs with a more fibrous content may have a more delayed enhancement that is best depicted on the delayed phase. Other PNETs can present as purely cystic, complex cystic and solid tumors and calcified tumors. Non-functioning PNETs are larger with less intense and more heterogeneous enhancement. Functional imaging is useful for disease staging, to detect disease recurrence or the primary but also to select patient candidate for peptide receptor radiometabolic treatment. Somatostatin receptor scintigraphy (SRS) (Octreoscan(®)) is still the most available technique. Gallium 68-SST analogue PET have been demonstrated to be more sensitive than SRS-SPEC and it will be the future of functional imaging for NET. Finally, (18)FDG PET/CT is indicated for more aggressive PNET as defined either by negative SRS and huge tumor burden or ki67 above 10% or poorly differentiated PNEC tumors.

Pubmed
Open Access
Yes
Create date
05/12/2016 21:59
Last modification date
20/08/2019 15:19
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