Assessing the consequences of gestational diabetes mellitus on offspring's cardiovascular health: MySweetHeart Cohort study protocol, Switzerland.

Détails

Ressource 1Télécharger: BIB_62291B0521BE.pdf (408.18 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_62291B0521BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Assessing the consequences of gestational diabetes mellitus on offspring's cardiovascular health: MySweetHeart Cohort study protocol, Switzerland.
Périodique
BMJ open
Auteur(s)
Di Bernardo S., Mivelaz Y., Epure A.M., Vial Y., Simeoni U., Bovet P., Estoppey Younes S., Chiolero A., Sekarski N.
Collaborateur(s)
MySweetHeart Research Group
ISSN
2044-6055 (Electronic)
ISSN-L
2044-6055
Statut éditorial
Publié
Date de publication
14/11/2017
Peer-reviewed
Oui
Volume
7
Numéro
11
Pages
e016972
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: epublish
Résumé
Gestational diabetes mellitus (GDM) is a state of glucose intolerance with onset during pregnancy. GDM carries prenatal and perinatal risks as well as long-term risks for the mother and her child. GDM may be involved in the foetal programming of long-term cardiovascular health. However, evidence is sparse and the effect of GDM on cardiovascular health is unknown. To address these issues, we will conduct MySweetHeart Cohort study. The objectives are to assess the effect of GDM on offspring's cardiovascular health early in life by using surrogate markers of cardiovascular disease and atherosclerosis.
This is a cohort study of 100 offspring of women with GDM and 100 offspring of women without GDM. At inclusion, a baseline assessment of the mothers will be conducted through means of self-report questionnaires, a researcher-administrated interview, blood pressure and anthropometric measurements, and a maternal blood sampling. Between the 30th and 34th weeks of gestation, a foetal echography will be performed to assess the foetal cardiac structure and function, the fetomaternal circulation and the hepatic volume. At birth, maternal and neonatal characteristics will be assessed. An echocardiography will be performed to assess cardiac structure and function 2-7 days after birth; carotid intima-media thickness will be also measured to assess vascular structure. MySweetHeart Cohort is linked to MySweetHeart Trial (clinicaltrials.gov/ct2/show/NCT02890693), a randomised controlled trial assessing the effect of a multidimensional interdisciplinary lifestyle and psychosocial intervention to improve the cardiometabolic and mental health of women with GDM and their offspring. A long-term follow-up of children is planned.
Ethical approval has been obtained through the state Human Research Ethics Committee of the Canton de Vaud (study number 2016-00745). We aim to disseminate the findings through regional, national and international conferences and through peer-reviewed journals.
ClinicalTrials.gov (clinicaltrials.gov/ct2/show/NCT02872974).
Mots-clé
Carotid Intima-Media Thickness, Diabetes, Gestational/blood, Echocardiography, Female, Fetal Development, Fetal Heart/diagnostic imaging, Fetal Heart/physiopathology, Heart Ventricles/diagnostic imaging, Humans, Infant Health, Infant, Newborn, Pregnancy, Prenatal Exposure Delayed Effects/diagnostic imaging, Prenatal Exposure Delayed Effects/physiopathology, Research Design, Switzerland, Ultrasonography, Prenatal, cardiovascular disease, carotid intima-media thickness, foetal programming, left ventricular mass index, paediatric
Pubmed
Web of science
Création de la notice
16/11/2017 20:19
Dernière modification de la notice
20/08/2019 14:19
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