Aspirin plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus.

Détails

ID Serval
serval:BIB_61D89C363FF6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Aspirin plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus.
Périodique
Pathogens and Disease
Auteur(s)
Veloso T.R., Oechslin F., Que Y.A., Moreillon P., Entenza J.M., Mancini S.
ISSN
2049-632X (Electronic)
ISSN-L
2049-632X
Statut éditorial
Publié
Date de publication
2015
Volume
73
Numéro
8
Pages
ftv060
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Enterococcus faecalis and Streptococcus gallolyticus cause infective endocarditis (IE), which can originate from the continuous release or translocation of low bacterial numbers into the bloodstream. In this context, IE cannot be prevented with antibiotics. We previously demonstrated that aspirin plus ticlopidine protected rats from IE due to S. gordonii and Staphylococcus aureus. Here we showed that aspirin plus ticlopidine significantly reduced vegetation weight and protected 73 and 64% rats (P < 0.005) from IE due to E. faecalis and S. gallolyticus, respectively. These results further support the potential use of aspirin plus ticlopidine for a global prevention of IE in high-risk patients.
Mots-clé
Animals, Aspirin/administration & dosage, Disease Models, Animal, Endocarditis, Bacterial/microbiology, Endocarditis, Bacterial/prevention & control, Enterococcus faecalis/growth & development, Female, Gram-Positive Bacterial Infections/microbiology, Gram-Positive Bacterial Infections/prevention & control, Platelet Aggregation Inhibitors/pharmacology, Rats, Wistar, Streptococcus/growth & development, Ticlopidine/administration & dosage, Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/11/2015 15:30
Dernière modification de la notice
08/05/2019 19:27
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