CUBN is a gene locus for albuminuria.

Böger, C.A.; Chen, M.H.; Tin, A.; Olden, M.; Köttgen, A.; de Boer, I.H.; Fuchsberger, C.; O'Seaghdha, C.M.; Pattaro, C.; Teumer, A.; Liu, C.T.; Glazer, N.L.; Li, M.; O'Connell, J.R.; Tanaka, T.; Peralta, C.A.; Kutalik, Z.; Luan, J.; Zhao, J.H.; Hwang, S.J.; Akylbekova, E.; Kramer, H.; van der Harst, P.; Smith, A.V.; Lohman, K.; de Andrade, M.; Hayward, C.; Kollerits, B.; Tönjes, A.; Aspelund, T.; Ingelsson, E.; Eiriksdottir, G.; Launer, L.J.; Harris, T.B.; Shuldiner, A.R.; Mitchell, B.D.; Arking, D.E.; Franceschini, N.; Boerwinkle, E.; Egan, J.; Hernandez, D.; Reilly, M.; Townsend, R.R.; Lumley, T.; Siscovick, D.S.; Psaty, B.M.; Kestenbaum, B.; Haritunians, T.; Bergmann, S.; Vollenweider, P.; Waeber, G.; Mooser, V.; Waterworth, D.; Johnson, A.D.; Florez, J.C.; Meigs, J.B.; Lu, X.; Turner, S.T.; Atkinson, E.J.; Leak, T.S.; Aasarød, K.; Skorpen, F.; Syvänen, A.C.; Illig, T.; Baumert, J.; Koenig, W.; Krämer, B.K.; Devuyst, O.; Mychaleckyj, J.C.; Minelli, C.; Bakker, S.J.; Kedenko, L.; Paulweber, B.; Coassin, S.; Endlich, K.; Kroemer, H.K.; Biffar, R.; Stracke, S.; Völzke, H.; Stumvoll, M.; Mägi, R.; Campbell, H.; Vitart, V.; Hastie, N.D.; Gudnason, V.; Kardia, S.L.; Liu, Y.; Polasek, O.; Curhan, G.; Kronenberg, F.; Prokopenko, I.; Rudan, I.; Arnlöv, J.; Hallan, S.; Navis, G.; Parsa, A.; Parsa, A.; Ferrucci, L.; Coresh, J.; Shlipak, M.G.; Bull, S.B.; Paterson, N.J.; Wichmann, H.E.; Wareham, N.J.; Loos, R.J.; Rotter, J.I.; Pramstaller, P.P.; Cupples, L.A.; Beckmann, J.S.; Yang, Q.; Heid, I.M.; Rettig, R.; Dreisbach, A.W.; Bochud, M.; Fox, C.S.; Kao, W.H.

doi:10.1681/ASN.2010060598

CUBN is a gene locus for albuminuria.

Details

Request a copy Under indefinite embargo.
UNIL restricted access
State: Public
Version: author

Serval ID

serval:BIB_61D7BB6FF101

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

CUBN is a gene locus for albuminuria.

Journal

Journal of the American Society of Nephrology

Author(s)

Böger C.A., Chen M.H., Tin A., Olden M., Köttgen A., de Boer I.H., Fuchsberger C., O'Seaghdha C.M., Pattaro C., Teumer A., Liu C.T., Glazer N.L., Li M., O'Connell J.R., Tanaka T., Peralta C.A., Kutalik Z., Luan J., Zhao J.H., Hwang S.J., Akylbekova E., Kramer H., van der Harst P., Smith A.V., Lohman K., de Andrade M., Hayward C., Kollerits B., Tönjes A., Aspelund T., Ingelsson E., Eiriksdottir G., Launer L.J., Harris T.B., Shuldiner A.R., Mitchell B.D., Arking D.E., Franceschini N., Boerwinkle E., Egan J., Hernandez D., Reilly M., Townsend R.R., Lumley T., Siscovick D.S., Psaty B.M., Kestenbaum B., Haritunians T., Bergmann S., Vollenweider P., Waeber G., Mooser V., Waterworth D., Johnson A.D., Florez J.C., Meigs J.B., Lu X., Turner S.T., Atkinson E.J., Leak T.S., Aasarød K., Skorpen F., Syvänen A.C., Illig T., Baumert J., Koenig W., Krämer B.K., Devuyst O., Mychaleckyj J.C., Minelli C., Bakker S.J., Kedenko L., Paulweber B., Coassin S., Endlich K., Kroemer H.K., Biffar R., Stracke S., Völzke H., Stumvoll M., Mägi R., Campbell H., Vitart V., Hastie N.D., Gudnason V., Kardia S.L., Liu Y., Polasek O., Curhan G., Kronenberg F., Prokopenko I., Rudan I., Arnlöv J., Hallan S., Navis G., Parsa A., Parsa A., Ferrucci L., Coresh J., Shlipak M.G., Bull S.B., Paterson N.J., Wichmann H.E., Wareham N.J., Loos R.J., Rotter J.I., Pramstaller P.P., Cupples L.A., Beckmann J.S., Yang Q., Heid I.M., Rettig R., Dreisbach A.W., Bochud M., Fox C.S., Kao W.H.

Working group(s)

CKDGen Consortium

Contributor(s)

Köttgen A., Pattaro C., Böger CA., Fuchsberger C., Olden M., Glazer NL., Parsa A., Gao X., Yang Q., Smith AV., O'Connell JR., Li M., Schmidt H., Tanaka T., Isaacs A., Ketkar S., Hwang SJ., Johnson AD., Dehghan A., Teumer A., Paré G., Aspelund T., Eiriksdottir G., Launer LJ., Harris TB., Rampersaud E., Mitchell BD., Boerwinkle E., Struchalin M., Cavalieri M., Singleton A., Giallauria F., Metter J., de Boer I., Haritunians T., Lumley T., Siscovick D., Psaty BM., Zillikens MC., Oostra BA., Feitosa M., Province M., Illig T., Klopp N., Meisinger C., Wichmann HE., Koenig W., Zgaga L., Zemunik T., Kolcic I., Minelli C., Johansson£££Åsa£££ Å. , Igl W., Zaboli G., Wild SH., Wright AF., Campbell H., Ellinghaus D., Schreiber S., Aulchenko YS., Felix JF., Rivadeneira F., Uitterlinden AG., Hofman A., Imboden M., Boban M., Campbell S., Endlich K., Völzke H., Kroemer HK., Nauck M., Völker U., Polasek O., Vitart V., Badola S., Parker AN., Ridker PM., Blankenberg S., Gudnason V., Shuldiner AR., Coresh J., Schmidt R., Ferrucci L., Shlipak MG., van Duijn CM. , Borecki I., Krämer BK., Rudan I., Gyllensten U., Wilson JF., Witteman JC., Pramstaller PP., Rettig R., Hastie ND., Chasman DI., Kao WH., Heid IM., Fox CS.

ISSN

1533-3450 (Electronic)

ISSN-L

1046-6673

Publication state

Published

Issued date

2011

Peer-reviewed

Oui

Volume

Number

Pages

555-570

Language

english

Notes

Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish

Abstract

Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 × 10(-11)) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.

Keywords

African Continental Ancestry Group/genetics, Albuminuria/genetics, European Continental Ancestry Group/genetics, Genetic Loci/genetics, Genetic Predisposition to Disease/genetics, Humans, Mutation, Missense/genetics, Receptors, Cell Surface/genetics

OAI-PMH

oai:serval.unil.ch:BIB_61D7BB6FF101

DOI

10.1681/ASN.2010060598

Pubmed

21355061

Web of science

000288778800023

Open Access

Yes

Create date

03/03/2011 9:45