Carotid plaque as a predictor of dementia in older adults: the Three-City Study.
Details
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_617E44DA8681
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Carotid plaque as a predictor of dementia in older adults: the Three-City Study.
Journal
Alzheimer's & dementia
ISSN
1552-5279 (Electronic)
ISSN-L
1552-5260
Publication state
Published
Issued date
03/2015
Peer-reviewed
Oui
Volume
11
Number
3
Pages
239-248
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The contribution of carotid atherosclerosis to incident dementia remains unclear. We examined the association between carotid plaques (CP) and common carotid intima media thickness (CCA-IMT) with incident dementia and its subtypes, and their added value for dementia risk prediction.
At baseline, 6025 dementia-free subjects aged 65-86 years underwent bilateral carotid ultrasonography measures of CP and plaque-free CCA-IMT. Subjects were followed-up over 7 years for the detection of dementia.
After a mean 5.4 years of follow-up, 421 subjects developed dementia including 272 Alzheimer's disease and 83 vascular/mixed dementia (VaD). Only CP were independently related to VaD (HR(≥2 sites with plaques) = 1.92; 95% confidence interval or CI = 1.13-3.22) and improved VaD risk prediction (continuous Net Reclassification Index = 30.1%; 95% CI = 8.4-51.7) beyond known dementia risk factors. Accounting for stroke or competing risk by death marginally modified the results.
In older adults, CP are independent predictors of incident VaD and may improve VaD risk prediction.
At baseline, 6025 dementia-free subjects aged 65-86 years underwent bilateral carotid ultrasonography measures of CP and plaque-free CCA-IMT. Subjects were followed-up over 7 years for the detection of dementia.
After a mean 5.4 years of follow-up, 421 subjects developed dementia including 272 Alzheimer's disease and 83 vascular/mixed dementia (VaD). Only CP were independently related to VaD (HR(≥2 sites with plaques) = 1.92; 95% confidence interval or CI = 1.13-3.22) and improved VaD risk prediction (continuous Net Reclassification Index = 30.1%; 95% CI = 8.4-51.7) beyond known dementia risk factors. Accounting for stroke or competing risk by death marginally modified the results.
In older adults, CP are independent predictors of incident VaD and may improve VaD risk prediction.
Keywords
Aged, Aged, 80 and over, Carotid Arteries/diagnostic imaging, Carotid Artery Diseases/diagnostic imaging, Carotid Artery Diseases/epidemiology, Carotid Intima-Media Thickness, Dementia/diagnosis, Dementia/diagnostic imaging, Dementia/epidemiology, Female, Follow-Up Studies, Humans, Incidence, Male, Plaque, Atherosclerotic/diagnostic imaging, Plaque, Atherosclerotic/epidemiology, Prognosis, Prospective Studies, Risk, Risk Factors, Sensitivity and Specificity, Aging, Atherosclerosis, Dementia, Epidemiology, Risk factors
Pubmed
Web of science
Create date
23/08/2024 8:49
Last modification date
23/08/2024 9:34
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