Finger doses due to 68Ga-labelled pharmaceuticals in PET departments, results of a multi-centre pilot study.

Details

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_617D974B29C0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Finger doses due to 68Ga-labelled pharmaceuticals in PET departments, results of a multi-centre pilot study.
Journal
Journal of radiological protection
Author(s)
McCann A., Cherbuin N., Covens P., Dabin J., Haruz-Waschitz S., Gallo L., Datz H., Wierts R., Wrzesien M., Zorz A., Cooke J., Dowling A., Kollaard R.
ISSN
1361-6498 (Electronic)
ISSN-L
0952-4746
Publication state
Published
Issued date
01/02/2023
Peer-reviewed
Oui
Volume
43
Number
1
Language
english
Notes
Publication types: Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Although the use of <sup>68</sup> Ga has increased substantially in nuclear medicine over the last decade, there is limited information available on occupational exposure due to <sup>68</sup> Ga. The purpose of this study is to determine the occupational extremity exposure during the preparation, dispensing and administration of <sup>68</sup> Ga-labelled radiopharmaceuticals.
Workers in eight centres wore a ring dosimeter for all tasks involving <sup>68</sup> Ga-labelled radiopharmaceuticals for a minimum of one month. Additionally, the fingertip dose was monitored in two centres and the hand with the highest ring dose during <sup>68</sup> Ga procedures was also identified in one centre.
The median normalised ring dose for <sup>68</sup> Ga procedures was found to be 0.25 mSv GBq <sup>-1</sup> (range 0.01-3.34). The normalised <sup>68</sup> Ga ring doses recorded in this study are similar to that found in the literature for <sup>18</sup> F. This study is consistent with previous findings that the highest extremity dose is found on the non-dominant hand. A limited sub study in two of the centres showed a median fingertip to base of the finger dose ratio of 4.3. Based on this median ratio, the extrapolated annual <sup>68</sup> Ga fingertip dose for 94% of the workers monitored in this study would be below Category B dose limit (150 mSv) and no worker would exceed Category A dose limit (500 mSv).
When appropriate shielding and radiation protection practices are employed, the extremity dose due to <sup>68</sup> Ga is comparable to that of <sup>18</sup> F and is expected to be well below the regulatory limits for the majority of workers.
Keywords
Humans, Radiopharmaceuticals, Pilot Projects, Pharmaceutical Preparations, Fingers, Positron-Emission Tomography, Occupational Exposure/analysis, Radiation Dosage, 68Ga, Hp(0.07), extremity dose, occupational exposure
Pubmed
Web of science
Open Access
Yes
Create date
23/01/2023 12:39
Last modification date
25/10/2023 7:16
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