Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Assessing ageing of individual T lymphocytes: Mission impossible?
Mechanisms of Ageing and Development
Effector T lymphocytes are the progeny of a limited number of antigen- specific precursor cells and it has been estimated that clonotypic human T cells may expand million fold on their way reaching high cell numbers that are sufficient for immune protection. Moreover, memory T cell responses are characterized by repetitive expansion of antigen-specific T cell clonotypes, and limitations in the proliferative capacity could lead to immune senescence. Because telomeres progressively shorten as a function of cell division, telomere length is a powerful indicator of the replicative in vivo history of human T lymphocytes. In this review, we summarize observations made over the last decade on telomere length dynamics of well-defined T cell populations derived from healthy donors and patients with infectious disease or cancer. We focus on T cell differentiation, T cell ageing, and natural and vaccine induced immune responses. We also discuss the scientific evidence for in vivo replicative senescence of antigen-specific T cells, and evaluate the available methods for measuring telomere lengths and telomerase activity, and their potential and limitations to increase our understanding of T cell physiology. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
human, T lymphocytes, naive, memory, antigen-specific, telomeres, replicative senescence, ageing, T cell differentiation, immunotherapy, T cell clonotypes, Telomerase Reverse-Transcriptase, In-Situ Hybridization, Cell Transfer Therapy, Flow Cytometric Analysis, Ex-Vivo Characterization, Replicative Senescence, Life-Span, Length Measurements, Human Fibroblasts, Dyskeratosis-Congenita
Web of science
Last modification date