Increased endometrial placenta growth factor (PLGF) gene expression in women with successful implantation.
Details
Serval ID
serval:BIB_61332DCA4A28
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Increased endometrial placenta growth factor (PLGF) gene expression in women with successful implantation.
Journal
Fertility and Sterility
ISSN
1556-5653 (Electronic)
ISSN-L
0015-0282
Publication state
Published
Issued date
2011
Volume
96
Number
3
Pages
663-668
Language
english
Abstract
Objective: To analyze the vascularization of the endometrium via hysteroscopy and to assess its correlation with angiogenic factor gene expression and embryo implantation rate.Design: Cross-sectional study.Setting: Public university hospital.Patient(s): Patients undergoing hysteroscopy for supposed infertility.Intervention(s): Endometrial quality assessment according to Sakumoto-Masamoto, performed in the early secretory phase of the cycle. Collection of an endometrial tissue biopsy.Main Outcome Measure(s): RNA extraction, reverse transcription, and determination of gene expression of angiogenesis- and implantation-relevant factors using quantitative polymerase chain reaction. Retrieval of pregnancy information from the medical records.Result(s): Good quantity/quality RNA with infertility history was obtained from 63 participating women. Those with a "good" endometrium and subsequent pregnancy showed increased gene expression for placenta growth factor when compared with patients with a "bad" endometrium and who did not succeed with pregnancy to date. Nonpregnant women with a "good" endometrium presented an intermediate result. No significant differences were observed for several other genes tested, but trends in the same direction were observed.Conclusion(s): This study demonstrates for the first time that endometrial PLGF expression corresponds to the hysteroscopic appearance of the endometrium, and therefore has potential as a clinically relevant prognosticator for infertility treatment success. (Fertil Steril (R) 2011;96:663-8. (C)2011 by American Society for Reproductive Medicine.)
Pubmed
Web of science
Create date
23/09/2011 13:03
Last modification date
20/08/2019 14:18