Sub-acute delayed failure of subthalamic DBS in Parkinson's disease: the role of micro-lesion effect.

Details

Serval ID
serval:BIB_6128EA051629
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sub-acute delayed failure of subthalamic DBS in Parkinson's disease: the role of micro-lesion effect.
Journal
Parkinsonism and Related Disorders
Author(s)
Granziera C., Pollo C., Russmann H., Staedler C., Ghika J., Villemure J.G., Burkhard P.R., Vingerhoets F.J.
ISSN
1353-8020 (Print)
ISSN-L
1353-8020
Publication state
Published
Issued date
2008
Volume
14
Number
2
Pages
109-113
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
OBJECTIVE: To study delayed failure after subthalamic nucleus (STN) deep brain stimulation in Parkinson's disease (PD) patients. METHODS: Out of 56 consecutive bilaterally STN-implanted PD patients, we selected subjects who, after initial clinical improvement (1 month after surgery), lost benefit (delayed failure, DF). RESULTS: Five patients developed sub-acutely severe gait disorders (DF). In 4/5 DF patients, a micro-lesion effect, defined as improvement without stimulation, was observed; immediate post-operative MRI demonstrated electrode located above or behind to the STN. CONCLUSIONS: Patients presenting micro-lesion effect should be carefully monitored, as this phenomenon can mask electrodes misplacement and evolution in DF
Keywords
Activities of Daily Living, Aged, Antiparkinson Agents/therapeutic use, Cohort Studies, Combined Modality Therapy, Electrodes, Implanted/adverse effects, Female, Follow-Up Studies, Gait Disorders, Neurologic/complications, Humans, Hypokinesia/complications, Male, Microelectrodes/adverse effects, Middle Aged, Parkinson Disease/psychology, Parkinson Disease/therapy, Stereotaxic Techniques, Subthalamic Nucleus/physiology, Treatment Failure
Pubmed
Web of science
Create date
29/01/2009 22:13
Last modification date
20/08/2019 14:18
Usage data