Article: article from journal or magazin.
Sub-acute delayed failure of subthalamic DBS in Parkinson's disease: the role of micro-lesion effect.
Parkinsonism and Related Disorders
Publication types: Journal Article Publication Status: ppublish
OBJECTIVE: To study delayed failure after subthalamic nucleus (STN) deep brain stimulation in Parkinson's disease (PD) patients. METHODS: Out of 56 consecutive bilaterally STN-implanted PD patients, we selected subjects who, after initial clinical improvement (1 month after surgery), lost benefit (delayed failure, DF). RESULTS: Five patients developed sub-acutely severe gait disorders (DF). In 4/5 DF patients, a micro-lesion effect, defined as improvement without stimulation, was observed; immediate post-operative MRI demonstrated electrode located above or behind to the STN. CONCLUSIONS: Patients presenting micro-lesion effect should be carefully monitored, as this phenomenon can mask electrodes misplacement and evolution in DF
Activities of Daily Living, Aged, Antiparkinson Agents/therapeutic use, Cohort Studies, Combined Modality Therapy, Electrodes, Implanted/adverse effects, Female, Follow-Up Studies, Gait Disorders, Neurologic/complications, Humans, Hypokinesia/complications, Male, Microelectrodes/adverse effects, Middle Aged, Parkinson Disease/psychology, Parkinson Disease/therapy, Stereotaxic Techniques, Subthalamic Nucleus/physiology, Treatment Failure
Web of science
Last modification date