Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib.
Publication types: Journal ArticlePublication Status: ppublish. pdf type: Case report
BRAF V600E is an emerging drug target in lung cancer, but the clinical significance of non-V600 BRAF mutations in lung cancer and other malignancies is less clear. Here, we report the case of a patient with metastatic lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib. We calculated a structure model of this very rare type of mutated BRAF kinase to explain the molecular mechanism of drug resistance. This information may help to develop effective targeted therapies for cancers with non-V600 BRAF mutations.
Web of science
Last modification date