The emerging role of multiplex tandem mass spectrometry analysis for therapeutic drug monitoring and personalized medicine

Détails

ID Serval
serval:BIB_61127FFB9A94
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The emerging role of multiplex tandem mass spectrometry analysis for therapeutic drug monitoring and personalized medicine
Périodique
TrAC Trends in Analytical Chemistry
Auteur(s)
Decosterd L.A., Widmer N., André P., Aouri M., Buclin T.
ISSN
0165-9936
Statut éditorial
Publié
Date de publication
11/2016
Peer-reviewed
Oui
Volume
84
Pages
5-13
Langue
anglais
Résumé
Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) constitutes now a key instrumental component of medical laboratory centres and has greatly facilitated the development of a considerable number of drugs assays for Therapeutic Drug Monitoring (TDM). The concept of TDM implies the measurement of concentrations of certain drugs in patients' blood, followed by dosage individualization based on patients' circulating exposure, targeting a pre-defined concentration range. This approach aims at increasing the likelihood of achieving therapeutic efficacy, while reducing the risk of toxicity. TDM can contribute to the rational individualization of critical drug treatments, notably antivirals, antibiotics, antiepileptics, psychotropic drugs and targeted anticancer agents, in the context of growing efforts towards personalized medicine. This article aims at reviewing the basic concepts, the role and the perspectives of evolution of TDM. It presents selected examples of clinical applications and gives some insights on how TDM is definitely benefiting from the tremendous development of LC-MS/MS techniques.
Mots-clé
Analytical Chemistry, Spectroscopy, Environmental Chemistry
Création de la notice
25/08/2016 8:55
Dernière modification de la notice
20/08/2019 14:18
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