Sleep reverts changes in human gray and white matter caused by wake-dependent training.

Détails

ID Serval
serval:BIB_609CC041670F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sleep reverts changes in human gray and white matter caused by wake-dependent training.
Périodique
NeuroImage
Auteur(s)
Bernardi G., Cecchetti L., Siclari F., Buchmann A., Yu X., Handjaras G., Bellesi M., Ricciardi E., Kecskemeti S.R., Riedner B.A., Alexander A.L., Benca R.M., Ghilardi M.F., Pietrini P., Cirelli C., Tononi G.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
01/04/2016
Volume
129
Pages
367-377
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Learning leads to rapid microstructural changes in gray (GM) and white (WM) matter. Do these changes continue to accumulate if task training continues, and can they be reverted by sleep? We addressed these questions by combining structural and diffusion weighted MRI and high-density EEG in 16 subjects studied during the physiological sleep/wake cycle, after 12 h and 24 h of intense practice in two different tasks, and after post-training sleep. Compared to baseline wake, 12 h of training led to a decline in cortical mean diffusivity. The decrease became even more significant after 24 h of task practice combined with sleep deprivation. Prolonged practice also resulted in decreased ventricular volume and increased GM and WM subcortical volumes. All changes reverted after recovery sleep. Moreover, these structural alterations predicted cognitive performance at the individual level, suggesting that sleep's ability to counteract performance deficits is linked to its effects on the brain microstructure. The cellular mechanisms that account for the structural effects of sleep are unknown, but they may be linked to its role in promoting the production of cerebrospinal fluid and the decrease in synapse size and strength, as well as to its recently discovered ability to enhance the extracellular space and the clearance of brain metabolites.

Mots-clé
Brain/physiopathology, Diffusion Magnetic Resonance Imaging, Electroencephalography, Female, Gray Matter/physiopathology, Humans, Image Processing, Computer-Assisted, Learning/physiology, Male, Sleep/physiology, Sleep Deprivation/physiopathology, Wakefulness, White Matter/physiopathology, Young Adult
Pubmed
Création de la notice
23/03/2017 18:27
Dernière modification de la notice
20/08/2019 15:17
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