Article: article from journal or magazin.
PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter.
PPARgamma is a member of the peroxisome proliferator activated receptors (PPAR) subfamily of nuclear receptors. So far two PPARgamma isoforms, PPARgamma1 and PPARgamma2, were known in mammals. We describe the structure of a novel human PPARgamma subtype, PPARgamma3. The PPARgamma3 mRNA is transcribed from a novel promoter localized 5' of exon A2. PPARgamma3 mRNA expression was restricted to adipose tissue and large intestine. Similar to human PPARgamma1 and -2, PPARy3 is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE.
5' Untranslated Regions/genetics, Adipose Tissue, Adult, Animals, Base Sequence, Cell Line, Dimerization, Exons/genetics, Humans, Intestine, Large, Molecular Sequence Data, Promoter Regions, Genetic/genetics, Prostaglandins/pharmacology, Protein Isoforms/genetics, RNA, Messenger/analysis, Receptors, Cytoplasmic and Nuclear/genetics, Receptors, Cytoplasmic and Nuclear/metabolism, Receptors, Retinoic Acid/metabolism, Response Elements/genetics, Retinoid X Receptors, Thiazoles/pharmacology, Thiazolidinediones, Transcription Factors/genetics, Transcription Factors/metabolism, Transcriptional Activation, Transfection, Tumor Cells, Cultured
Web of science
Last modification date