PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter.
Details
Serval ID
serval:BIB_609731CAB2A7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter.
Journal
FEBS Letters
ISSN
0014-5793 (Print)
ISSN-L
0014-5793
Publication state
Published
Issued date
1998
Volume
438
Number
1-2
Pages
55-60
Language
english
Abstract
PPARgamma is a member of the peroxisome proliferator activated receptors (PPAR) subfamily of nuclear receptors. So far two PPARgamma isoforms, PPARgamma1 and PPARgamma2, were known in mammals. We describe the structure of a novel human PPARgamma subtype, PPARgamma3. The PPARgamma3 mRNA is transcribed from a novel promoter localized 5' of exon A2. PPARgamma3 mRNA expression was restricted to adipose tissue and large intestine. Similar to human PPARgamma1 and -2, PPARy3 is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE.
Keywords
5' Untranslated Regions/genetics, Adipose Tissue, Adult, Animals, Base Sequence, Cell Line, Dimerization, Exons/genetics, Humans, Intestine, Large, Molecular Sequence Data, Promoter Regions, Genetic/genetics, Prostaglandins/pharmacology, Protein Isoforms/genetics, RNA, Messenger/analysis, Receptors, Cytoplasmic and Nuclear/genetics, Receptors, Cytoplasmic and Nuclear/metabolism, Receptors, Retinoic Acid/metabolism, Response Elements/genetics, Retinoid X Receptors, Thiazoles/pharmacology, Thiazolidinediones, Transcription Factors/genetics, Transcription Factors/metabolism, Transcriptional Activation, Transfection, Tumor Cells, Cultured
Pubmed
Web of science
Create date
07/03/2013 17:10
Last modification date
20/08/2019 15:17
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