Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials
Details
Serval ID
serval:BIB_5FA3F222A499
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials
Journal
Diabetic Medicine
ISSN
0742-3071
Publication state
Published
Issued date
06/2009
Volume
26
Number
6
Pages
617-621
Language
english
Notes
453fv
Times Cited:39
Cited References Count:13
Times Cited:39
Cited References Count:13
Abstract
Rigorous assessment of health-related quality of life (HRQL) is mandatory to establish the benefits of islet transplantation.
The 36-Item Short Form Health Survey (SF-36) and the Diabetes Quality of Life (DQOL) scales were completed by patients included in an Islet Transplantation Alone (ITA) trial (n = 10) and an Islet After Kidney (IAK) trial (n = 10).
The two populations differed by HRQL scores at baseline, with poorer scores in ITA patients. SF-36 scores for physical limitations, bodily pain, general health perception, social functioning, and health transition improved significantly in ITA patients 6 and 12 months post transplantation. The DQOL global score was significantly improved at 6 months and remained so at 12 months, because of a significant improvement in the dimensions of satisfaction and impact of diabetes. No improvement was observed in the IAK patients.
HRQL assessment may help in the selection of candidates with brittle diabetes for islet transplantation.
The 36-Item Short Form Health Survey (SF-36) and the Diabetes Quality of Life (DQOL) scales were completed by patients included in an Islet Transplantation Alone (ITA) trial (n = 10) and an Islet After Kidney (IAK) trial (n = 10).
The two populations differed by HRQL scores at baseline, with poorer scores in ITA patients. SF-36 scores for physical limitations, bodily pain, general health perception, social functioning, and health transition improved significantly in ITA patients 6 and 12 months post transplantation. The DQOL global score was significantly improved at 6 months and remained so at 12 months, because of a significant improvement in the dimensions of satisfaction and impact of diabetes. No improvement was observed in the IAK patients.
HRQL assessment may help in the selection of candidates with brittle diabetes for islet transplantation.
Keywords
health-related quality of life, pancreatic islet transplantation, type 1 diabetes mellitus
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Create date
14/06/2021 9:58
Last modification date
18/09/2021 6:38
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