From Viral Infection to Skin Affliction: Unveiling Mechanisms of Cutaneous Manifestations in COVID-19 and Post-COVID Conditions.
Details
Serval ID
serval:BIB_5F72C7C735B7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
From Viral Infection to Skin Affliction: Unveiling Mechanisms of Cutaneous Manifestations in COVID-19 and Post-COVID Conditions.
Journal
The Journal of investigative dermatology
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Publication state
Published
Issued date
02/2025
Peer-reviewed
Oui
Volume
145
Number
2
Pages
257-265
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
COVID-19 skin manifestations are multifaceted, ranging from urticaria, morbilliform or papulovesicular rash, livedoid purpuric lesions, and to pseudochilblains (also called COVID toes). Recent insights into the mechanism of these manifestations have highlighted that morbilliform, papulovesicular, and livedoid/purpuric rashes are related to virus-induced endothelial cell damage and linked to moderate-to-severe disease, whereas pseudochilblains are related to an exaggerated IFN-1 production by plasmacytoid dendritic cells in protected individuals. In this paper, we will review the clinical and physiopathological features of cutaneous COVID-19 manifestations in relation to the direct viral cytopathic effects and dysregulated IFN-1 responses. We will also review the emerging insights into post-COVID conditions (also termed long COVID) and how they may be implicated in the persistence of COVID-19-associated skin diseases.
Keywords
Humans, COVID-19/complications, COVID-19/immunology, COVID-19/virology, SARS-CoV-2, Skin Diseases/virology, Skin Diseases/immunology, Skin/pathology, Skin/virology, Skin/immunology, Post-Acute COVID-19 Syndrome, Urticaria/virology, Urticaria/pathology, Urticaria/immunology, Interferon Type I/metabolism, Interferon Type I/immunology, Acute COVID-19, Dermatology, Immunology, Long COVID
Pubmed
Create date
16/12/2024 16:38
Last modification date
28/01/2025 7:06