Topical administration of isoflavones for treatment of vaginal symptoms in postmenopausal women: A systematic review of randomised controlled trials.

Details

Serval ID
serval:BIB_5F62E8E07D7A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Topical administration of isoflavones for treatment of vaginal symptoms in postmenopausal women: A systematic review of randomised controlled trials.
Journal
Journal of obstetrics and gynaecology
Author(s)
Ghazanfarpour M., Latifnejad Roudsari R., Treglia G., Sadeghi R.
ISSN
1364-6893 (Electronic)
ISSN-L
0144-3615
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
35
Number
8
Pages
783-787
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Current systematic review evaluated the efficacy of topical isoflavones to relieve vaginal symptoms in menopausal women. MEDLINE (1966 to January 2014), Scopus (1990 to January 2014), and the Cochrane Central Register of Controlled Trials (The Cochrane Library issue 1, 2013) were searched using keywords 'isoflavone and vagina'. Relevant studies were reviewed by two independent reviewers. Only randomised controlled trials (RCTs) were included in the systematic review. Out of 115 potentially relevant publications, four studies met the inclusion criteria. Topical isoflavones showed beneficial effects on dyspareunia, vaginal dryness and maturation value. Based on only one trial, the result of conjugated equine oestrogen cream (0.3 mg/day) was similar to use of isoflavone vaginal gel and superior to that of placebo gel. However, drawing any definite conclusion was difficult because of the limited number of RCTs, the small sample sizes, weak methodology and considerable heterogeneity of the included studies.

Keywords
Atrophy/drug therapy, Dyspareunia/drug therapy, Female, Humans, Isoflavones/administration & dosage, Postmenopause, Randomized Controlled Trials as Topic, Vagina/drug effects, Vagina/pathology, Vaginal Diseases/drug therapy, Isoflavone, menopause, systematic review, topical, vaginal symptoms
Pubmed
Web of science
Create date
20/08/2017 17:10
Last modification date
20/08/2019 14:17
Usage data