Improved biocompatibility of heparin surface-coated ventricular assist devices.

Details

Serval ID
serval:BIB_5F442D2330DE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Improved biocompatibility of heparin surface-coated ventricular assist devices.
Journal
International Journal of Artificial Organs
Author(s)
Von Segesser L.K., Weiss B.M., Hänseler E., Bisang B., Leskosek B., Von Felten A., Turina M.
ISSN
0391-3988 (Print)
ISSN-L
0391-3988
Publication state
Published
Issued date
1992
Peer-reviewed
Oui
Volume
15
Number
5
Pages
301-306
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Heparin surface coated ventricular assist devices (VADs) and cannulas were evaluated in comparison to uncoated VADs in 10 bovine experiments (body weight 77 +/- 6 kg). All systems were primed with cristalloid solution. No systemic heparin was given. Left ventricular assist was started with a blood flow of 4.2 +/- 0.4 l/min and maintained over 6 hours. Besides hemodynamic monitoring, blood samples were taken at regular intervals for blood gas, hematological, biochemical and coagulation studies. All animals in the study group (coated) were assisted for the scheduled 6 hours without device failure. In the control group, however, total occlusion occurred in 1 VAD after 1 hour of left ventricular assist whereas the other 4 VADs remained functional throughout the protocol. Mixed venous oxygens saturation was preassist 56 +/- 12% for coated versus 63 +/- 11% for uncoated and the final value at 60 minutes after weaning was 58 +/- 16% versus 59 +/- 5% (NS). Mean hematocrit dropped from a baseline value of 33 +/- 4% for coated versus 29 +/- 8% for uncoated to 29 +/- 7% versus 30 +/- 5% (NS) after 6 hours of assist. There was no significant difference between the baseline values (5.7 +/- 3.0 mumol/l for coated versus 4.6 +/- 3.1 mumol/l for uncoated) and the 6-hour values (3.8 +/- 3.7 mumol/l versus 7.6 +/- 6.4 mumol/l) for mean plasma hemoglobine. The normalized platelet levels dropped after 10 minutes of assist to 91 +/- 21% for coated versus 94 +/- 49% for uncoated (NS) and 89 +/- 29% versus 65 +/- 44 at 6 hours (NS).(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Animals, Biocompatible Materials, Cattle, Heart-Assist Devices, Hemodynamics, Heparin, Prosthesis Failure, Thrombosis/prevention & control
Pubmed
Web of science
Create date
14/02/2008 14:16
Last modification date
20/08/2019 14:17
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