Acute CNS axonal injury models a subtype of dystrophic neurite in Alzheimer's disease.
Details
Serval ID
serval:BIB_5E949F83B599
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acute CNS axonal injury models a subtype of dystrophic neurite in Alzheimer's disease.
Journal
Alzheimer 's Reports
ISSN
1461-6130
Publication state
Published
Issued date
2000
Volume
3
Number
1
Pages
31-40
Language
english
Abstract
The morphological and neurochemical sequelae of physical injury to cortical axons were investigated for their similarity to a subtype of dystrophic neurite in Alzheimer's disease (AD). A 25 gauge needle was inserted into the cortex of anaesthetised rats for 10 min. At 1 day post-injury, neurofilament-immunoreactive bulb- and ring-like abnormal neurites were present along the needle tract edge. Double labelling immunohistochemistry demonstrated colocalisation of neurofilament subunits with different phosphorylation states within the same reactive axonal structures. Ultrastructurally, bulb-like axons contained neurofilaments and abnormal structures such as dense-core vesicles and multilamellar bodies. Ring-like structures corresponded to collapsed myelinated axons or axon terminals, with bands of neurofilaments surrounding central mitochondria and/or other organelles, All of these reactive axons lacked microtubules. The morphological, neurochemical and ultrastructural features of axons responding to physical trauma resemble the cellular alterations within a subset of dystrophic neurites in AD, particularly in the early stages of the condition.
Keywords
Alzheimer's diseasebeta-amyloiddystrophic neuriteimmunohistochemistryneurofilamentphysical damage
Web of science
Create date
24/01/2008 14:35
Last modification date
09/05/2023 5:53