Acute CNS axonal injury models a subtype of dystrophic neurite in Alzheimer's disease.

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Serval ID
serval:BIB_5E949F83B599
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acute CNS axonal injury models a subtype of dystrophic neurite in Alzheimer's disease.
Journal
Alzheimer 's Reports
Author(s)
King C. E., Dickson T. C., Jacobs I., McCormack G. H., Riederer B. M., Vickers J. C.
ISSN
1461-6130
Publication state
Published
Issued date
2000
Volume
3
Number
1
Pages
31-40
Language
english
Abstract
The morphological and neurochemical sequelae of physical injury to cortical axons were investigated for their similarity to a subtype of dystrophic neurite in Alzheimer's disease (AD). A 25 gauge needle was inserted into the cortex of anaesthetised rats for 10 min. At 1 day post-injury, neurofilament-immunoreactive bulb- and ring-like abnormal neurites were present along the needle tract edge. Double labelling immunohistochemistry demonstrated colocalisation of neurofilament subunits with different phosphorylation states within the same reactive axonal structures. Ultrastructurally, bulb-like axons contained neurofilaments and abnormal structures such as dense-core vesicles and multilamellar bodies. Ring-like structures corresponded to collapsed myelinated axons or axon terminals, with bands of neurofilaments surrounding central mitochondria and/or other organelles, All of these reactive axons lacked microtubules. The morphological, neurochemical and ultrastructural features of axons responding to physical trauma resemble the cellular alterations within a subset of dystrophic neurites in AD, particularly in the early stages of the condition.
Keywords
Alzheimer's diseasebeta-amyloiddystrophic neuriteimmunohistochemistryneurofilamentphysical damage
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Create date
24/01/2008 14:35
Last modification date
09/05/2023 5:53
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