SFE/SFHTA/AFCE primary aldosteronism consensus: Introduction and handbook.

Details

Serval ID
serval:BIB_5E77715BCDCD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
SFE/SFHTA/AFCE primary aldosteronism consensus: Introduction and handbook.
Journal
Annales d'endocrinologie
Author(s)
Amar L., Baguet J.P., Bardet S., Chaffanjon P., Chamontin B., Douillard C., Durieux P., Girerd X., Gosse P., Hernigou A., Herpin D., Houillier P., Jeunemaitre X., Joffre F., Kraimps J.L., Lefebvre H., Ménégaux F., Mounier-Véhier C., Nussberger J., Pagny J.Y., Pechère A., Plouin P.F., Reznik Y., Steichen O., Tabarin A., Zennaro M.C., Zinzindohoue F., Chabre O.
ISSN
2213-3941 (Electronic)
ISSN-L
0003-4266
Publication state
Published
Issued date
07/2016
Peer-reviewed
Oui
Volume
77
Number
3
Pages
179-186
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication types: Consensus Development Conference ; Journal Article ; Practice Guideline

Abstract
The French Endocrinology Society (SFE) French Hypertension Society (SFHTA) and Francophone Endocrine Surgery Association (AFCE) have drawn up recommendations for the management of primary aldosteronism (PA), based on an analysis of the literature by 27 experts in 7 work-groups. PA is suspected in case of hypertension associated with one of the following characteristics: severity, resistance, associated hypokalemia, disproportionate target organ lesions, or adrenal incidentaloma with hypertension or hypokalemia. Diagnosis is founded on aldosterone/renin ratio (ARR) measured under standardized conditions. Diagnostic thresholds are expressed according to the measurement units employed. Diagnosis is established for suprathreshold ARR associated with aldosterone concentrations >550pmol/L (200pg/mL) on 2 measurements, and rejected for aldosterone concentration<240pmol/L (90pg/mL) and/or subthreshold ARR. The diagnostic threshold applied is different if certain medication cannot be interrupted. In intermediate situations, dynamic testing is performed. Genetic forms of PA are screened for in young subjects and/or in case of familial history. The patient should be informed of the results expected from medical and surgical treatment of PA before exploration for lateralization is proposed. Lateralization is explored by adrenal vein sampling (AVS), except in patients under 35 years of age with unilateral adenoma on imaging. If PA proves to be lateralized, unilateral adrenalectomy may be performed, with adaptation of medical treatment pre- and postoperatively. If PA is non-lateralized or the patient refuses surgery, spironolactone is administered as first-line treatment, replaced by amiloride, eplerenone or calcium-channel blockers if insufficiently effective or poorly tolerated.

Keywords
Adrenal Gland Neoplasms, Adrenalectomy, Adult, Aldosterone/blood, Calcium Channel Blockers/therapeutic use, France, Humans, Hyperaldosteronism/diagnosis, Hyperaldosteronism/therapy, Hypertension, Hypokalemia, Mineralocorticoid Receptor Antagonists/therapeutic use, Renin/blood, Spironolactone/therapeutic use
Pubmed
Create date
24/06/2016 9:31
Last modification date
21/08/2019 6:15
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