Mixed myelodysplastic syndrome and myeloproliferative disorder with bone marrow and pulmonary fibrosis: the role of megakaryocytes.
Details
Serval ID
serval:BIB_5E39F8D16084
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Mixed myelodysplastic syndrome and myeloproliferative disorder with bone marrow and pulmonary fibrosis: the role of megakaryocytes.
Journal
Acta Haematologica
ISSN
0001-5792 (Print)
ISSN-L
0001-5792
Publication state
Published
Issued date
2003
Volume
109
Number
3
Pages
145-149
Language
english
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Abstract
The case of an 80-year-old woman displaying myelodysplastic syndrome evolving into a myeloproliferative disorder with myelofibrosis and pulmonary fibrosis, is reported. This case is characterized by an initial presentation of a myelodysplastic syndrome with normal karyotype and moderate fibrosis, its evolution towards a myeloproliferative disorder with myelofibrosis and the worsening of pulmonary fibrosis in parallel to the acceleration of the myeloproliferative disorder and myelofibrosis. These features and the high concentration of plasma platelet factor-4 suggest a role of megakaryocyte/platelet degranulation in the development of fibrosis.
Keywords
Aged, Aged, 80 and over, Cell Degranulation, Female, Humans, Megakaryocytes/pathology, Megakaryocytes/physiology, Myelodysplastic Syndromes/complications, Myeloproliferative Disorders/etiology, Myeloproliferative Disorders/pathology, Platelet Factor 4/metabolism, Primary Myelofibrosis/etiology, Primary Myelofibrosis/pathology, Pulmonary Fibrosis/etiology, Pulmonary Fibrosis/pathology, Time Factors
Pubmed
Web of science
Create date
20/10/2015 13:50
Last modification date
20/08/2019 15:16
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