Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Mixed myelodysplastic syndrome and myeloproliferative disorder with bone marrow and pulmonary fibrosis: the role of megakaryocytes.
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
The case of an 80-year-old woman displaying myelodysplastic syndrome evolving into a myeloproliferative disorder with myelofibrosis and pulmonary fibrosis, is reported. This case is characterized by an initial presentation of a myelodysplastic syndrome with normal karyotype and moderate fibrosis, its evolution towards a myeloproliferative disorder with myelofibrosis and the worsening of pulmonary fibrosis in parallel to the acceleration of the myeloproliferative disorder and myelofibrosis. These features and the high concentration of plasma platelet factor-4 suggest a role of megakaryocyte/platelet degranulation in the development of fibrosis.
Aged, Aged, 80 and over, Cell Degranulation, Female, Humans, Megakaryocytes/pathology, Megakaryocytes/physiology, Myelodysplastic Syndromes/complications, Myeloproliferative Disorders/etiology, Myeloproliferative Disorders/pathology, Platelet Factor 4/metabolism, Primary Myelofibrosis/etiology, Primary Myelofibrosis/pathology, Pulmonary Fibrosis/etiology, Pulmonary Fibrosis/pathology, Time Factors
Web of science
Last modification date