Different molecular profiles characterize well-differentiated endocrine tumors and poorly differentiated endocrine carcinomas of the gastroenteropancreatic tract.

Détails

ID Serval
serval:BIB_5E3109A71119
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Different molecular profiles characterize well-differentiated endocrine tumors and poorly differentiated endocrine carcinomas of the gastroenteropancreatic tract.
Périodique
Clinical Cancer Research : An Official Journal of the American Association For Cancer Research
Auteur(s)
Furlan D., Cerutti R., Uccella S., La Rosa S., Rigoli E., Genasetti A., Capella C.
ISSN
1078-0432 (Print)
ISSN-L
1078-0432
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
10
Numéro
3
Pages
947-957
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
PURPOSE: The molecular pathogenesis of gastroenteropancreatic endocrine tumors (ETs) is still largely unknown. The purpose of this work was a molecular characterization of 38 gastroenteropancreatic ETs with respect to the primary site and to the morphofunctional profile, pointing out useful diagnostic or prognostic molecular markers.
EXPERIMENTAL DESIGN: Twenty-four well-differentiated ETs or carcinomas (WDET/Cs; 11 pancreatic, 3 gastric, and 10 intestinal) and 14 poorly differentiated endocrine carcinomas (1 pancreatic, 6 gastric, and 7 colorectal) were microallelotyped using 38 polymorphic microsatellite markers covering chromosomes 1, 3, 5q, 6, 11, 17, and 18.
RESULTS: Regardless of the primary site, a significantly higher percentage of allelic imbalances (AIs) was observed in poorly differentiated endocrine carcinomas than in WDET/Cs (P = 0.012), except for 3 of 8 nonfunctioning pancreatic endocrine tumors and 1 colorectal WDEC, exhibiting multiple AIs on chromosomes 1, 3, 6, and 11. A strong positive correlation between AI percentage and Ki-67 proliferation index was detected considering both the whole series of ETs (P = 0.004) and the group of WDET/Cs alone (P = 0.011). The survival analysis showed a positive correlation between low percentage of AI and longer survival (P = 0.01). No recurrent AIs at specific chromosomal regions were identifiable with respect to the primary site.
CONCLUSIONS: The malignant progression of endocrine tumors seems to be associated with complex allelotypes and chromosomal instability. Although no specific molecular markers of malignancy can be defined with certainty, the ploidy status and the degree of chromosomal derangements appear to be the most informative genetic factors with prognostic significance.
Mots-clé
Adult, Aged, Alleles, Biomarkers, Tumor/metabolism, Cell Differentiation, Female, Genetic Markers, Humans, Immunohistochemistry, Ki-67 Antigen/biosynthesis, Male, Microsatellite Repeats, Middle Aged, Models, Genetic, Neuroendocrine Tumors/pathology, Pancreatic Neoplasms/pathology, Polymerase Chain Reaction, Polymorphism, Genetic, Prognosis, Time Factors
Pubmed
Web of science
Création de la notice
07/09/2016 8:04
Dernière modification de la notice
20/08/2019 14:16
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